Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation

G. Filaci, P. Contini, S. Brenci, L. Lanza, M. Scudeletti, F. Indiveri, F. Puppo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

HLA class I and class II antigens circulate in serum as soluble molecules. Increased concentrations of soluble HLA class I molecules have been demonstrated in viral diseases, in rejection episodes following organ transplantation and in graft versus host disease. To explore the possibility of a variation of the serum concentrations of soluble HLA class II molecules in the same pathologic conditions we developed a double determinant immune assay that detects whole soluble HLA-DR molecules (sHLA-DR). The mean level of sHLA-DR antigens in sera from 23 healthy individuals was 0.64 ± 0.72 μg/ml. Elevated serum concentrations of sHLA-DR molecules were detected in sera from HIV infected patients in CDC2/3 and in CDC4 C1 stages (2.0 ± 1.7 μg/ml and 4.6 ± 1.7 μg/ml, respectively), in sera from patients affected by acute rejection after liver transplantation (5.3 ± 3.7 μg/ml) and in sera from patients affected by severe acute graft versus host disease following bone marrow transplantation (8.8 ± 3.1 μg/ml). The increase of sHLA-DR molecules in these sera significantly correlated with the elevation of soluble HLA class I antigens (P=0.0004). The reported data suggest that both soluble HLA class I and class II molecules serum levels increase during viral infections and strong immune reactions and could suggest the involvement of these molecules in immunoregulation.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalTissue Antigens
Volume46
Issue number2
Publication statusPublished - 1995

Fingerprint

HLA-DR Antigens
HIV Infections
Transplantation
Molecules
Serum
Transplantation (surgical)
Graft vs Host Disease
Virus Diseases
Grafts
Histocompatibility Antigens Class I
Antigen-antibody reactions
Histocompatibility Antigens Class II
Organ Transplantation
HLA Antigens
Bone Marrow Transplantation
Liver Transplantation
Liver
HIV
Assays
Bone

Keywords

  • GVHD
  • HIV
  • HLA antigen
  • Transplantation

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Filaci, G., Contini, P., Brenci, S., Lanza, L., Scudeletti, M., Indiveri, F., & Puppo, F. (1995). Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation. Tissue Antigens, 46(2), 117-123.

Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation. / Filaci, G.; Contini, P.; Brenci, S.; Lanza, L.; Scudeletti, M.; Indiveri, F.; Puppo, F.

In: Tissue Antigens, Vol. 46, No. 2, 1995, p. 117-123.

Research output: Contribution to journalArticle

Filaci, G, Contini, P, Brenci, S, Lanza, L, Scudeletti, M, Indiveri, F & Puppo, F 1995, 'Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation', Tissue Antigens, vol. 46, no. 2, pp. 117-123.
Filaci G, Contini P, Brenci S, Lanza L, Scudeletti M, Indiveri F et al. Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation. Tissue Antigens. 1995;46(2):117-123.
Filaci, G. ; Contini, P. ; Brenci, S. ; Lanza, L. ; Scudeletti, M. ; Indiveri, F. ; Puppo, F. / Increased serum concentration of soluble HLA-DR antigens in HIV infection and following transplantation. In: Tissue Antigens. 1995 ; Vol. 46, No. 2. pp. 117-123.
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