Increased serum ferritin is common in men with essential hypertension

Alberto Piperno, Paola Trombini, Marisa Gelosa, Viviana Mauri, Valeria Pecci, Anna Vergani, Alessandra Salvioni, Raffaella Mariani, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


Objectives: Insulin-resistance-associated hepatic iron overload syndrome (IRHIO) is characterized by high serum ferritin and presence of metabolic alterations that are part of insulin-resistance syndrome (IRS). Thus, clinical conditions characterized by a high prevalence of IRS may also be characterized by a high prevalence of IRHIO. Design and methods: We studied 88 consecutive patients with essential hypertension, 62 patients with IRHIO and 102 healthy normotensive controls. Hemochromatosis, other conditions able to induce secondary iron overload or serum ferritin increase unrelated to body iron stores were excluded. Iron indices, metabolic profiles and hepatic tests in hypertensive with or without increased serum ferritin and in IRHIO with and without hypertension were studied. Metabolic variables, serum iron indices, liver function tests and hepatic ultrasound data were analysed. Data were compared by non-parametric tests. Results: In men with hypertension, increased serum ferritin was more frequent than in controls (21 versus 0%, P = 0.001). Hypertensive men with increased serum ferritin had more frequent and pronounced metabolic alterations than those with normal serum ferritin, the metabolic abnormalities and serum ferritin being frequently positively correlated. In hypertensive men with increased serum ferritin, metabolic and iron data were similar to those of IRHIO patients with hypertension. Conclusions: In males, hypertension is characterized by a higher prevalence of increased iron stores and metabolic abnormalities that are part of the IRHIO syndrome. This finding may have clinical implications due to the increased risk of IRHIO patients to develop hepatic cirrhosis and also for the role of iron in early atherogenesis.

Original languageEnglish
Pages (from-to)1513-1518
Number of pages6
JournalJournal of Hypertension
Issue number8
Publication statusPublished - Aug 2002


  • Essential hypertension
  • Insulin resistance syndrome
  • Iron overload
  • Metabolic disorders
  • Serum ferritin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology


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