Increased serum inflammatory markers as predictors of airway obstruction

Mara De Amici, Remigio Moratti, Silvana Quaglini, Roberta Alesina, Vittoria Peona

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recruitment and activation of both neutrophils and eosinophils seem to be a characteristic of chronic bronchitis. The purpose of this study was to evaluate whether eosinophil cationic protein and/or myeloperoxidase (ECP/MPO) serum levels differ between patients with chronic obstructive and nonobstructive bronchitis during an exacerbation-free period and if they represent clinical gravity indicators of disease. To identify a correlation between ECP/MPO values in serum and bronco-obstruction, a statistical analysis by logistic regression was used. Study results show that there is a relationship between increased serum levels of ECP and log MPO and an increased risk for forced expiratory volume in 1 second (FEV1) pathologic values associated with obstructive chronic bronchitis, with an ECP odds ratio = 1.04 and logMPO = 4.45.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalJournal of Asthma
Volume43
Issue number8
DOIs
Publication statusPublished - Sep 1 2006

Fingerprint

Airway Obstruction
Eosinophil Cationic Protein
Biomarkers
Chronic Bronchitis
Peroxidase
Serum
Neutrophil Activation
Bronchitis
Forced Expiratory Volume
Gravitation
Eosinophils
Logistic Models
Odds Ratio

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Increased serum inflammatory markers as predictors of airway obstruction. / De Amici, Mara; Moratti, Remigio; Quaglini, Silvana; Alesina, Roberta; Peona, Vittoria.

In: Journal of Asthma, Vol. 43, No. 8, 01.09.2006, p. 593-596.

Research output: Contribution to journalArticle

De Amici, Mara ; Moratti, Remigio ; Quaglini, Silvana ; Alesina, Roberta ; Peona, Vittoria. / Increased serum inflammatory markers as predictors of airway obstruction. In: Journal of Asthma. 2006 ; Vol. 43, No. 8. pp. 593-596.
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