Increased serum level of xanthine oxidoreductase in liver transplanted patients

Maria Giulia Battelli, M. Ravaioli, S. Musiani, V. Scicchitano, G. L. Grazi, A. Bolognesi

Research output: Contribution to journalArticlepeer-review

Abstract

Xanthine oxidoreductase (XOR) leakage into serum has been observed in various types of liver pathology as well as after liver transplantation (LT). We determined the amount of XOR associated with LT to investigate the changes in serum enzyme level during the LT procedure and the post-operative period. Additionally, we examined whether there was any correlation between XOR levels and the surgical technique. XOR levels were measured by a competitive ELISA. In a first group of patients, the portal vein was flushed before the liver and systemic reperfusions, which occurred simultaneously. In the second group, the graft was flushed with blood from the portal vein before the systemic reperfusion. XOR showed a marked elevation in the caval effluent collected during LT and was higher compared to control serum levels at all time points that were examined after LT. The XOR levels during LT were also higher than samples taken pre-LT or from the portal blood flush before reperfusion. The XOR level was higher in Group 2 than in Group 1. Enhancement of the XOR serum level during LT was not derived from enterocytes, and it should be attributed to enzyme leakage from graft liver cells. We report the elevation of serum XOR during the three weeks following LT for the first time, as well as the influence of the graft reperfusion technique on XOR serum level.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalJournal of Biological Regulators and Homeostatic Agents
Volume25
Issue number1
Publication statusPublished - Jan 2011

Keywords

  • Cirrhosis
  • Hepatocellular carcinoma
  • Liver transplantation
  • Serum markers
  • Xanthine oxidoreduciase

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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