Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients

Morgane Roulot, Alessandra Minelli, Marco Bortolomasi, Elisabetta Maffioletti, Massimo Gennarelli, Marc Borsotto, Catherine Heurteaux, Jean Mazella

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Sortilin-derived propeptide (PE) and its synthetic analog spadin show strong antidepressant activity in rodents and, therefore, could be used as a biomarker to evaluate the clinical efficacy of antidepressant treatments. The aim of this study was to determine whether electroconvulsive therapy (ECT) modulates serum PE concentration in patients with treatment-resistant depression (TRD). Patients and methods: Forty-five patients with major depressive disorder, who met the Diagnostic and Statistical Manual of Mental Disorders-IV criteria, were selected for this study. Results: We did not observe any difference in the PE levels between TRD patients and controls (z=0.10, P=0.92), but we found a strong significant increase between the PE levels measured just before (T0) and about 1 month (T2) after ECT (z=-2.82, P=0.005). A significant difference between T0 and T2 was observed only in responders (z=-2.59, P=0.01), whereas no effect was found in nonresponders (z=-1.27, P=0.20). Interestingly, we found a significant correlation between the increase in PE levels and decrease in Montgomery-Åsberg Depression Rating Scale scores for the total patient sample (P=0.03). Conclusion: This study indicates for the first time that ECT affects serum PE concentration in responders and, therefore, could contribute to the evaluation of the therapy success.

Original languageEnglish
Pages (from-to)2307-2312
Number of pages6
JournalNeuropsychiatric Disease and Treatment
Volume14
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Electroconvulsive Therapy
Treatment-Resistant Depressive Disorder
Serum
Antidepressive Agents
Therapeutics
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Rodentia
Biomarkers
sortilin
Depression

Keywords

  • Diagnosis
  • Electroconvulsive therapy
  • Sortilin propeptide
  • Treatment-resistant depressed patients

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients. / Roulot, Morgane; Minelli, Alessandra; Bortolomasi, Marco; Maffioletti, Elisabetta; Gennarelli, Massimo; Borsotto, Marc; Heurteaux, Catherine; Mazella, Jean.

In: Neuropsychiatric Disease and Treatment, Vol. 14, 01.01.2018, p. 2307-2312.

Research output: Contribution to journalArticle

Roulot, Morgane ; Minelli, Alessandra ; Bortolomasi, Marco ; Maffioletti, Elisabetta ; Gennarelli, Massimo ; Borsotto, Marc ; Heurteaux, Catherine ; Mazella, Jean. / Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients. In: Neuropsychiatric Disease and Treatment. 2018 ; Vol. 14. pp. 2307-2312.
@article{34577f8e7fa844f69bc9ce516f7660dd,
title = "Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients",
abstract = "Purpose: Sortilin-derived propeptide (PE) and its synthetic analog spadin show strong antidepressant activity in rodents and, therefore, could be used as a biomarker to evaluate the clinical efficacy of antidepressant treatments. The aim of this study was to determine whether electroconvulsive therapy (ECT) modulates serum PE concentration in patients with treatment-resistant depression (TRD). Patients and methods: Forty-five patients with major depressive disorder, who met the Diagnostic and Statistical Manual of Mental Disorders-IV criteria, were selected for this study. Results: We did not observe any difference in the PE levels between TRD patients and controls (z=0.10, P=0.92), but we found a strong significant increase between the PE levels measured just before (T0) and about 1 month (T2) after ECT (z=-2.82, P=0.005). A significant difference between T0 and T2 was observed only in responders (z=-2.59, P=0.01), whereas no effect was found in nonresponders (z=-1.27, P=0.20). Interestingly, we found a significant correlation between the increase in PE levels and decrease in Montgomery-{\AA}sberg Depression Rating Scale scores for the total patient sample (P=0.03). Conclusion: This study indicates for the first time that ECT affects serum PE concentration in responders and, therefore, could contribute to the evaluation of the therapy success.",
keywords = "Diagnosis, Electroconvulsive therapy, Sortilin propeptide, Treatment-resistant depressed patients",
author = "Morgane Roulot and Alessandra Minelli and Marco Bortolomasi and Elisabetta Maffioletti and Massimo Gennarelli and Marc Borsotto and Catherine Heurteaux and Jean Mazella",
year = "2018",
month = "1",
day = "1",
doi = "10.2147/NDT.S170165",
language = "English",
volume = "14",
pages = "2307--2312",
journal = "Neuropsychiatric Disease and Treatment",
issn = "1176-6328",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Increased serum levels of sortilin-derived propeptide after electroconvulsive therapy in treatment-resistant depressed patients

AU - Roulot, Morgane

AU - Minelli, Alessandra

AU - Bortolomasi, Marco

AU - Maffioletti, Elisabetta

AU - Gennarelli, Massimo

AU - Borsotto, Marc

AU - Heurteaux, Catherine

AU - Mazella, Jean

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: Sortilin-derived propeptide (PE) and its synthetic analog spadin show strong antidepressant activity in rodents and, therefore, could be used as a biomarker to evaluate the clinical efficacy of antidepressant treatments. The aim of this study was to determine whether electroconvulsive therapy (ECT) modulates serum PE concentration in patients with treatment-resistant depression (TRD). Patients and methods: Forty-five patients with major depressive disorder, who met the Diagnostic and Statistical Manual of Mental Disorders-IV criteria, were selected for this study. Results: We did not observe any difference in the PE levels between TRD patients and controls (z=0.10, P=0.92), but we found a strong significant increase between the PE levels measured just before (T0) and about 1 month (T2) after ECT (z=-2.82, P=0.005). A significant difference between T0 and T2 was observed only in responders (z=-2.59, P=0.01), whereas no effect was found in nonresponders (z=-1.27, P=0.20). Interestingly, we found a significant correlation between the increase in PE levels and decrease in Montgomery-Åsberg Depression Rating Scale scores for the total patient sample (P=0.03). Conclusion: This study indicates for the first time that ECT affects serum PE concentration in responders and, therefore, could contribute to the evaluation of the therapy success.

AB - Purpose: Sortilin-derived propeptide (PE) and its synthetic analog spadin show strong antidepressant activity in rodents and, therefore, could be used as a biomarker to evaluate the clinical efficacy of antidepressant treatments. The aim of this study was to determine whether electroconvulsive therapy (ECT) modulates serum PE concentration in patients with treatment-resistant depression (TRD). Patients and methods: Forty-five patients with major depressive disorder, who met the Diagnostic and Statistical Manual of Mental Disorders-IV criteria, were selected for this study. Results: We did not observe any difference in the PE levels between TRD patients and controls (z=0.10, P=0.92), but we found a strong significant increase between the PE levels measured just before (T0) and about 1 month (T2) after ECT (z=-2.82, P=0.005). A significant difference between T0 and T2 was observed only in responders (z=-2.59, P=0.01), whereas no effect was found in nonresponders (z=-1.27, P=0.20). Interestingly, we found a significant correlation between the increase in PE levels and decrease in Montgomery-Åsberg Depression Rating Scale scores for the total patient sample (P=0.03). Conclusion: This study indicates for the first time that ECT affects serum PE concentration in responders and, therefore, could contribute to the evaluation of the therapy success.

KW - Diagnosis

KW - Electroconvulsive therapy

KW - Sortilin propeptide

KW - Treatment-resistant depressed patients

UR - http://www.scopus.com/inward/record.url?scp=85057566229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057566229&partnerID=8YFLogxK

U2 - 10.2147/NDT.S170165

DO - 10.2147/NDT.S170165

M3 - Article

AN - SCOPUS:85057566229

VL - 14

SP - 2307

EP - 2312

JO - Neuropsychiatric Disease and Treatment

JF - Neuropsychiatric Disease and Treatment

SN - 1176-6328

ER -