Increased sodium requirement following early postnatal surgical correction of congenital uropathies in infants

F. Terzi, B. M. Assael, A. Claris-Appiani, G. Marra, C. A. Dell'Agnola, B. Tadini, V. Tomaselli

Research output: Contribution to journalArticlepeer-review

Abstract

Serum electrolyte equilibrium and plasma aldosterone concentrations were monitored in 19 infants who had severe obstructive uropathy or grade 5 vesico-ureteral reflux and were undergoing surgical correction in the first 2 months of life. Before surgery high plasma aldosterone levels were observed in 8 patients, but serum sodium and potassium concentrations were normal. Plasma concentrations of aldosterone were elevated in all patients during the week following surgery and 7 patients developed severe hyponatraemia, hyperkalaemia and weight loss despite very high plasma aldosterone concentrations. As a consequence 5 infants were infused with sodium chloride (4 mEq/kg per day) before and for 36h after surgery; this prevented metabolic imbalance. We conclude that infants undergoing surgical correction of uropathies may require a high sodium intake to maintain electrolyte balance and adequate growth.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalPediatric Nephrology
Volume4
Issue number6
DOIs
Publication statusPublished - Nov 1990

Keywords

  • Aldosterone
  • Obstructive uropathy
  • Serum electrolytes
  • Sodium chloride infusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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