Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Katleen De Gaetano Donati; Ricardo Rabagliati; Mario Tumbarello; Evelina Tacconelli; Concetta Amore; Roberto Cauda; Licia Lacoviello

doi:10.1097/00002030-200303280-00020

Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Katleen De Gaetano Donati, Ricardo Rabagliati, Mario Tumbarello, Evelina Tacconelli, Concetta Amore, Roberto Cauda, Licia Lacoviello

www.neuromed.it

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Abstract

Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.

Original language	English
Pages (from-to)	765-768
Number of pages	4
Journal	AIDS (London, England)
Volume	17
Issue number	5
DOIs	https://doi.org/10.1097/00002030-200303280-00020
Publication status	Published - Mar 28 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy. / De Gaetano Donati, Katleen; Rabagliati, Ricardo; Tumbarello, Mario; Tacconelli, Evelina; Amore, Concetta; Cauda, Roberto; Lacoviello, Licia.

In: AIDS (London, England), Vol. 17, No. 5, 28.03.2003, p. 765-768.

Research output: Contribution to journal › Article › peer-review

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AU - Amore, Concetta

AU - Cauda, Roberto

AU - Lacoviello, Licia

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