Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Katleen De Gaetano Donati; Ricardo Rabagliati; Mario Tumbarello; Evelina Tacconelli; Concetta Amore; Roberto Cauda; Licia Lacoviello

doi:10.1097/00002030-200303280-00020

Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Katleen De Gaetano Donati, Ricardo Rabagliati, Mario Tumbarello, Evelina Tacconelli, Concetta Amore, Roberto Cauda, Licia Lacoviello

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Abstract

Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.

Original language	English
Pages (from-to)	765-768
Number of pages	4
Journal	AIDS (London, England)
Volume	17
Issue number	5
DOIs	https://doi.org/10.1097/00002030-200303280-00020
Publication status	Published - Mar 28 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.",

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AU - De Gaetano Donati, Katleen

AU - Rabagliati, Ricardo

AU - Tumbarello, Mario

AU - Tacconelli, Evelina

AU - Amore, Concetta

AU - Cauda, Roberto

AU - Lacoviello, Licia

PY - 2003/3/28

Y1 - 2003/3/28

N2 - Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.

AB - Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.

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Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Abstract

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