Increased soluble markers of endothelial dysfunction in HIV-positive patients under highly active antiretroviral therapy

Katleen De Gaetano Donati, Ricardo Rabagliati, Mario Tumbarello, Evelina Tacconelli, Concetta Amore, Roberto Cauda, Licia Lacoviello

Research output: Contribution to journalArticlepeer-review

Abstract

Higher levels of soluble adhesion molecules have been found before the introduction of highly active antiretroviral therapy (HAART) in HIV-positive compared with HIV-negative patients. To evaluate the impact of HAART on endothelial function we measured the plasmatic concentrations of soluble adhesion molecules in 120 HIV-positive patients. Concentrations of P-selectin and fibrinolytic factors were significantly higher in HAART patients, whereas soluble intercellular adhesion molecule-1 did not differ significantly. HAART may induce an activation of endothelial function both directly and indirectly through lipid alterations.

Original languageEnglish
Pages (from-to)765-768
Number of pages4
JournalAIDS (London, England)
Volume17
Issue number5
DOIs
Publication statusPublished - Mar 28 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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