Increased soluble P-selectin levels in hepatitis C virus-related chronic hepatitis: Correlation with viral load

P. Ferroni, A. Mammarella, F. Martini, V. Paoletti, C. M. Cardarello, G. Labbadia, L. Donnarumma, A. De Matteis, P. P. Gazzaniga, A. Musca, S. Basili

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Platelet functional abnormalities are commonly found in patients with chronic liver disease; however, their nature and clinical significance are still a matter of discussion. Methods: Soluble P-selectin (sP-selectin, a marker of in vivo platelet activation) levels, lipid pattern, and clotting activity were investigated in 39 patients with histologically confirmed chronic C hepatitis. Results: Serum factor VIIc (P3/μL). Platelet-associated immunoglobulin G (PAIgG) was present in 30.8% of patients. Plasma sP-selectin levels were higher in hepatitis C patients compared with controls (P

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalJournal of Investigative Medicine
Volume49
Issue number5
Publication statusPublished - 2001

Keywords

  • Cholesterol
  • Hemostatic abnormalities
  • Liver disease
  • Platelet activation
  • Thrombocytopenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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