Increased spatial resolution using a 3-D Ti-weighted gradient-echo sequence results in greater hypointense lesion volumes in multiple sclerosis

M. Filippi, M. A. Rocca, M. A. Horsfield, M. Rovaris, G. Mastronardo, N. Canal, G. Comi

Research output: Contribution to journalArticle

Abstract

It has been demonstrated that the accumulation of hypointense lesions on T l-weighted spin-echo magnetic resonance imaging (MRI) of the brain with conventional slice thickness strongly correlates with disease progression in multiple sclerosis (MS) and that reducing slice thickness allows the detection of more lesions and higher lesion volumes on both unenhanced T2 and enhanced Tl-weighted scans. In this study, we used a magnetization-prepared rapid acquisition gradient echo (MP RAGE) sequence with subsequent reconstruction of axial slices with 5, 3 and 1 mm thickness in 16 patients with MS to evaluate whether improved spatial resolution also results in the detection of higher volumes of hypo-intense lesions . The median volume of hypointense lesions increased from 1190 mm3 (range=0-14918 mnr) on 5 mm MP RAGE to 1733 mm3 (range=0-15758 mm3) on 3 mm MPRAGE and to 1862 mm3 (range=17-16208 mm3) (p=0.0001). The hypointense lesion volumes measured on the three MP RAGE scans correlated significantly with the degree of disability (SRCC=0.58, p=0.02), while this correlation was not significant with the T2-weighted lesion load (SRCC=0.37). These data indicate that a significant volume of potentially disabling MS lesions is not measured when performing MR scans with conventional slice thickness.

Original languageEnglish
Pages (from-to)40
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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