Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients.

Carmen Galbusera, Maurizio Facheris, Fulvio Magni, Gloria Galimberti, Gessica Sala, Lucia Tremolada, Valeria Isella, Franca Rosa Guerini, Ildebrando Appollonio, Marzia Galli-Kienle, Carlo Ferrarese

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Abstract

Oxidative stress, linked to Abeta-lipid interactions, plays a pathogenetic role in Alzheimer's disease. We investigated modifications of lipid peroxidation products in plasma of 52 AD patients, 42 healthy controls and 16 patients with amyotrophic lateral sclerosis, a neurodegenerative disease where oxidative stress also plays a pathogenetic role. Final lipid peroxidation products were measured in plasma by thiobarbituric acid reactive substances (TBARS) assay before and after ex vivo oxidative stress catalysed by copper. There were no significant changes at basal conditions, but after copper-induced oxidation TBARS levels were higher in AD patients (19.0 microM +/- 2.2) versus both controls (5.2 microM +/- 0.8, p

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalExp Clin Transplant
Volume1
Issue number2
Publication statusPublished - May 2004

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ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Galbusera, C., Facheris, M., Magni, F., Galimberti, G., Sala, G., Tremolada, L., Isella, V., Guerini, F. R., Appollonio, I., Galli-Kienle, M., & Ferrarese, C. (2004). Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients. Exp Clin Transplant, 1(2), 103-109.