AUMENTO DELLO SOGLIA DI ATTIVAZIONE CORTICALE ALLA STIMOLAZIONE MAGNETICA TRANSOSSEA IN PAZIENTI CON EPILESSIA IN TRATTAMENTO FARMACOLOGICO CRONICO

Translated title of the contribution: Increased threshold intensity to transcranial magnetic stimulation in drug-treated with epilepsy patients

R. Michelucci, G. Rubboli, A. Forti, R. Plasmati, F. Salvi, L. Parmeggiani, D. Passarelli, G. Plazzi, P. Riguzzi, A. M. Buzzi, C. A. Tassinari

Research output: Contribution to journalArticle

Abstract

Transcranial Magnetic Stimulation of the cerebral cortex was performed in 103 patients with idiopathic generalized epilepsy (60 cases) and cryptogenic partial epilepsy (43 cases). Of them, 21 did not take any drug, 47 assumed one drug, 29 two drugs and 6 three or more drugs. A control group consisting of 33 healthy subjects was also stimulated. In each patient and control subject we studied the latency of motor evoked potentials, the central conduction time and the threshold of activation of motor responses. The latency and central conduction time were normal in epileptic patients, whereas the threshold intensity was significantly higher in drug-treated epileptics as compared to control subjects and untreated epileptics. We conclude that anticonvulsant drugs may influence the excitability of the cerebral cortex.

Original languageItalian
Pages (from-to)191-192
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number70-71
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Clinical Neurology

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