Increased thrombin generation in inflammatory bowel diseases

Simone Saibeni, Valeria Saladino, Veena Chantarangkul, Federica Villa, Savino Bruno, Maurizio Vecchi, Roberto de Franchis, Cinzia Sei, Armando Tripodi

Research output: Contribution to journalArticle


Background: Inflammatory bowel diseases (IBD) are characterized by an increased thrombotic risk of uncertain etiology. Endogenous thrombin potential (ETP), a parameter of the thrombin generation curve, represents a new tool in the evaluation of thrombotic and bleeding disorders. Aims: To study ETP in IBD patients and to correlate the results with clinical and biochemical features. Methods: Seventy-four IBD patients (37 ulcerative colitis and 37 Crohn's disease) and 74 sex- and age-matched healthy individuals. ETP was measured upon activation of coagulation with small amounts of tissue factor and phospholipids in the presence or absence of thrombomodulin; results were expressed as nM thrombin·minutes. Results: Mean±SD ETP values were significantly higher in patients (1,499 ± 454) than controls (1,261 ± 385) (p <0.001) only when the test was performed in the presence of thrombomodulin. ETP evaluated as ratio (with/without thrombomodulin), taken as an index of hypercoagulability, was significantly higher in patients (0.69 ± 0.14) than controls (0.62 ± 0.18) (p <0.006). Patients with increased C-reactive protein (CRP) had significantly higher mean ETP (1,721 ± 458) than those with normal CRP (1,357 ± 394) or controls (1,261 ± 385) (p <0.001). Patients who at the time of blood sampling were classified as having a clinically active disease had ETP higher than those who were quiescent (1,655 ± 451 versus 1,388 ± 427, p <0.001) or controls (1,261 ± 385, p <0.001). Conclusions: ETP measured in the presence of thrombomodulin or as ratio (with/without thrombomodulin) is increased in IBD patients, mainly in those with increased CRP or active disease. It may be considered as a candidate test for prospective studies aimed at assessing the risk of thrombosis in IBD patients.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalThrombosis Research
Issue number3
Publication statusPublished - Mar 2010


  • Inflammation
  • Inflammatory bowel diseases
  • Thrombin generation

ASJC Scopus subject areas

  • Hematology

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    Saibeni, S., Saladino, V., Chantarangkul, V., Villa, F., Bruno, S., Vecchi, M., de Franchis, R., Sei, C., & Tripodi, A. (2010). Increased thrombin generation in inflammatory bowel diseases. Thrombosis Research, 125(3), 278-282.