Increased thromboxane a2 generation and altered membrane fatty acid composition in platelets from patients with active angina pectoris

Domenico Prisco, Pier Giorgio Rogasi, Marzia Matucci, Rosanna Abbate, Gian Franco Gensini, Gian Gastone Neri Serneri

Research output: Contribution to journalArticlepeer-review

Abstract

Lipid composition of platelet membranes and thromboxane A2 (TxA2) generation by platelets were investigated in eighty-seven anginal patients (forty-two with resting angina in active phase and forty-five with effort stable angina or rest angina in inactive phase) and in forty-five clinically healthy subjects of similar age. All subjects were on the same dietary regimen and the adherence to diet was checked by analysis of red blood cell lipids. Platelets from active angina patients produced more TxA2 than platelets from both inactive patients and controls (p

Original languageEnglish
Pages (from-to)101-112
Number of pages12
JournalThrombosis Research
Volume44
Issue number1
DOIs
Publication statusPublished - Oct 1 1986

Keywords

  • angina pectoris
  • arachidonic acid
  • phospholipids
  • Platelet lipids
  • polyunsaturated fatty acids
  • thromboxane A2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Fingerprint Dive into the research topics of 'Increased thromboxane a2 generation and altered membrane fatty acid composition in platelets from patients with active angina pectoris'. Together they form a unique fingerprint.

Cite this