Increased total serum immunoglobulin E in children developing mycoplasma pneumoniae-related extra-pulmonary diseases

Dimitri Poddighe, Elena Virginia Comi, Ilaria Brambilla, Amelia Licari, Paola Bruni, Gian Luigi Marseglia

Research output: Contribution to journalArticlepeer-review


Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly. Based upon clinical and serology aspects, 3 groups of children were identified: I) with non-mycoplasma respiratory disease; II) with mycoplasma-related respiratory diseases; III) with extra-pulmonary diseases related to concomitant/recent Mycoplasma pneumoniae infection. Interestingly, children with Mycoplasma pneumoniae-related extra-pulmonary diseases showed a significant elevation of total serum IgE. In particular, patients developing Mycoplasma pneumoniae-related extra-pulmonary diseases (group III) showed significantly higher level of IgE than both previous groups (p<0.001 vs. group I; p<0.01 vs. group II). In conclusion, hospitalized children diagnosed with Mycoplasma pneumoniae-related extrapulmonary diseases resulted to have significantly increased serum IgE compared to children developing respiratory illnesses only.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalIranian Journal of Allergy, Asthma and Immunology
Issue number5
Publication statusPublished - Oct 1 2018


  • Children
  • Extra-pulmonary diseases
  • Immunoglobulin E
  • Mycoplasma pneumoniae
  • Post-infectious immune-mediated diseases

ASJC Scopus subject areas

  • Immunology and Allergy


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