Increased urinary prostaglandin excretion in galactose-fed rats

P. G. Zager, R. P. Eaton, H. J. Frey, M. Scavini, J. E. Jackson

Research output: Contribution to journalArticlepeer-review

Abstract

Increased renal production of prostaglandins (PG) may contribute to the hyperfiltration that accompanies early diabetes. It was posulated that a putative metabolic abnormality of diabetes, ie, increased flux through the polyol pathway, stimulates renal PG production and that this phenomenon can be prevented by aldose-reductase inhibition. To test this hypothesis, the effects of polyol accumulation on urinary excretion rates (UER) of PGE2 and 6-keto-PGF were studied, using the galactose-fed rat model. UER of PGE2 and 6-keto-PGF were measured in three groups of weanling Wister male rats. Group 1 was maintained on normal chow (n = 6), group 2 was fed chow supplemented with 30% galactose (n = 6), and group 3 received chow supplemented with 30% galactose and 0.7% sorbinil (n = 6). Ten 24-hour urine samples were obtained from each group between 151 and 240 days on the respective diets. UER of PGE2 (P <.001) and 6-keto-PGF (P <.01) were higher in group 2 than in group 1. UER of PGE2 (NS) and 6-keto-PGF (NS), respectively, were similar in groups 1 and 3. These data indicate that flux through the polyol pathway modulates the UER of PGE2 and 6-keto-PGF. This phemonenon may contribute to the glomerular hyperfiltration of early diabetes.

Original languageEnglish
Pages (from-to)603-605
Number of pages3
JournalMetabolism
Volume38
Issue number7
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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