In this study performed in rats, we measured extracellular lactate levels within different brain areas after a variety of stimuli using microdialysis. Experiments were performed using natural, physiological stimulation and experimental convulsive seizures. Generalized and limbic seizures produced a pronounced increase in lactic acid and a similar increase was obtained when the animals underwent olfactory stimulation. Increase in lactic acid occurred with site specificity and crucially relied on the quality of the stimulus.
|Translated title of the contribution||Increases in extracellular lactate as an index of neuronal activity in awake freely moving animals|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology