Il lattato extracellulare come indice di attivita neuronale nell'animale sveglio e libero di muoversi

Translated title of the contribution: Increases in extracellular lactate as an index of neuronal activity in awake freely moving animals

F. Fornai, L. Bassi, R. Guerrini, M. G. Alessandri, G. U. Corsini

Research output: Contribution to journalArticle

Abstract

In this study performed in rats, we measured extracellular lactate levels within different brain areas after a variety of stimuli using microdialysis. Experiments were performed using natural, physiological stimulation and experimental convulsive seizures. Generalized and limbic seizures produced a pronounced increase in lactic acid and a similar increase was obtained when the animals underwent olfactory stimulation. Increase in lactic acid occurred with site specificity and crucially relied on the quality of the stimulus.

Original languageItalian
Pages (from-to)233-235
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number99
Publication statusPublished - 1997

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Lactic Acid
Seizures
Microdialysis
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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keywords = "Anaerobic metabolism, Brain dialysis, Extracellular lactate, Limbic epilepsy, Neuronal metabolism",
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T1 - Il lattato extracellulare come indice di attivita neuronale nell'animale sveglio e libero di muoversi

AU - Fornai, F.

AU - Bassi, L.

AU - Guerrini, R.

AU - Alessandri, M. G.

AU - Corsini, G. U.

PY - 1997

Y1 - 1997

N2 - In this study performed in rats, we measured extracellular lactate levels within different brain areas after a variety of stimuli using microdialysis. Experiments were performed using natural, physiological stimulation and experimental convulsive seizures. Generalized and limbic seizures produced a pronounced increase in lactic acid and a similar increase was obtained when the animals underwent olfactory stimulation. Increase in lactic acid occurred with site specificity and crucially relied on the quality of the stimulus.

AB - In this study performed in rats, we measured extracellular lactate levels within different brain areas after a variety of stimuli using microdialysis. Experiments were performed using natural, physiological stimulation and experimental convulsive seizures. Generalized and limbic seizures produced a pronounced increase in lactic acid and a similar increase was obtained when the animals underwent olfactory stimulation. Increase in lactic acid occurred with site specificity and crucially relied on the quality of the stimulus.

KW - Anaerobic metabolism

KW - Brain dialysis

KW - Extracellular lactate

KW - Limbic epilepsy

KW - Neuronal metabolism

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JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

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