Abstract
Context: Although obesity is associated with high bone mass, recent reports suggest an increase in the incidence of fractures in obese patients. Copyright
Objectives: The objectives of the study were to evaluate the influence of increasing body fat on bone mineral density (BMD) and to determine the influence of the different adipokines on BMD in frail obese elderly patients.
Design and Setting: This is a cross-sectional study of baseline characteristics of elderly obese patients participating in a lifestyle therapy with diet with or without exercise and conducted in a university setting.
Patients: One hundred seventy-three, elderly (≥65 y old), obese (body mass index of ≥30 kg/m2) who were mostly frail participated in the study.
Outcome Measures: BMD, percentage of total body fat, percentage of fat-free mass, percentage of lean mass, body mass index, adiponectin, leptin, IL-6, bone turnover markers (osteocalcin and C-telopeptide), high-sensitivity C-reactive protein, free estradiol, and 25-hydroxyvitamin D were measured.
Results: Higher tertiles of percentagebodyfatandlower lean masswereassociated with a lowerBMD. High-sensitivity C-reactive protein levels were highest in the highest fat tertile (third, 5.5±5.4 vs first, 1.5±1.3 mg/L, P
Conclusions: Increasing adiposity together with decreasing lean mass is associated with lower BMD, higher adipokine levels, and worsening frailty in elderly obese adults.
| Original language | English |
|---|---|
| Pages (from-to) | 3290-3297 |
| Number of pages | 8 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 99 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2014 |
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ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
- Medicine(all)
Cite this
Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults. / Aguirre, Lina; Napoli, Nicola; Waters, Debra; Qualls, Clifford; Villareal, Dennis T.; Armamento-Villareal, Reina.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 9, 01.09.2014, p. 3290-3297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults
AU - Aguirre, Lina
AU - Napoli, Nicola
AU - Waters, Debra
AU - Qualls, Clifford
AU - Villareal, Dennis T.
AU - Armamento-Villareal, Reina
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Context: Although obesity is associated with high bone mass, recent reports suggest an increase in the incidence of fractures in obese patients. CopyrightObjectives: The objectives of the study were to evaluate the influence of increasing body fat on bone mineral density (BMD) and to determine the influence of the different adipokines on BMD in frail obese elderly patients.Design and Setting: This is a cross-sectional study of baseline characteristics of elderly obese patients participating in a lifestyle therapy with diet with or without exercise and conducted in a university setting.Patients: One hundred seventy-three, elderly (≥65 y old), obese (body mass index of ≥30 kg/m2) who were mostly frail participated in the study.Outcome Measures: BMD, percentage of total body fat, percentage of fat-free mass, percentage of lean mass, body mass index, adiponectin, leptin, IL-6, bone turnover markers (osteocalcin and C-telopeptide), high-sensitivity C-reactive protein, free estradiol, and 25-hydroxyvitamin D were measured.Results: Higher tertiles of percentagebodyfatandlower lean masswereassociated with a lowerBMD. High-sensitivity C-reactive protein levels were highest in the highest fat tertile (third, 5.5±5.4 vs first, 1.5±1.3 mg/L, PConclusions: Increasing adiposity together with decreasing lean mass is associated with lower BMD, higher adipokine levels, and worsening frailty in elderly obese adults.
AB - Context: Although obesity is associated with high bone mass, recent reports suggest an increase in the incidence of fractures in obese patients. CopyrightObjectives: The objectives of the study were to evaluate the influence of increasing body fat on bone mineral density (BMD) and to determine the influence of the different adipokines on BMD in frail obese elderly patients.Design and Setting: This is a cross-sectional study of baseline characteristics of elderly obese patients participating in a lifestyle therapy with diet with or without exercise and conducted in a university setting.Patients: One hundred seventy-three, elderly (≥65 y old), obese (body mass index of ≥30 kg/m2) who were mostly frail participated in the study.Outcome Measures: BMD, percentage of total body fat, percentage of fat-free mass, percentage of lean mass, body mass index, adiponectin, leptin, IL-6, bone turnover markers (osteocalcin and C-telopeptide), high-sensitivity C-reactive protein, free estradiol, and 25-hydroxyvitamin D were measured.Results: Higher tertiles of percentagebodyfatandlower lean masswereassociated with a lowerBMD. High-sensitivity C-reactive protein levels were highest in the highest fat tertile (third, 5.5±5.4 vs first, 1.5±1.3 mg/L, PConclusions: Increasing adiposity together with decreasing lean mass is associated with lower BMD, higher adipokine levels, and worsening frailty in elderly obese adults.
UR - http://www.scopus.com/inward/record.url?scp=84907211270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907211270&partnerID=8YFLogxK
U2 - 10.1210/jc.2013-3200
DO - 10.1210/jc.2013-3200
M3 - Article
C2 - 24878039
AN - SCOPUS:84907211270
VL - 99
SP - 3290
EP - 3297
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 9
ER -