Increasing dosages of low-molecular-weight heparin in hospitalized patients with Covid-19

Ida Martinelli, Alessandro Ciavarella, Maria Abbattista, Stefano Aliberti, Valentina De Zan, Christian Folli, Mauro Panigada, Andrea Gori, Andrea Artoni, Anna Maria Ierardi, Gianpaolo Carrafiello, Valter Monzani, Giacomo Grasselli, Francesco Blasi, Flora Peyvandi

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted an observational cohort study in adult patients consecutively admitted for the respiratory illness Covid-19 to our hub hospital from March 9 to April 7, 2020. The high observed rate of venous thromboembolism prompted us to increase the prophylactic doses of enoxaparin from 40 mg daily up to 1 mg/kg twice daily in patients admitted to intensive care units (ICU), 0.7 mg/kg twice daily in high-intensity of care wards and 1 mg/kg daily in low-intensity of care wards. Patients on high enoxaparin doses were compared to those who received prophylaxis with the standard dosage. Efficacy endpoints were mortality, clinical deterioration, and the occurrence of venous thromboembolism, safety endpoint was the occurrence of major bleeding. Of 278 patients with Covid-19, 127 received prophylaxis with high enoxaparin doses and 151 with standard dosage. At 21 days, the incidence rate of death and clinical deterioration were lower in patients on higher doses than in those on the standard dosage (hazard ratio 0.39, 95% confidence interval 0.23–0.62), and the incidence of venous thromboembolism was also lower (hazard ratio 0.52, 95% confidence interval 0.26–1.05). Major bleeding occurred in four of 127 patients (3.1%) on the high enoxaparin dosage. In conclusion, in the cohort of patients with Covid-19 treated with high enoxaparin dosages we observed a 60% reduction of mortality and clinical deterioration and a 50% reduction of venous thromboembolism compared to standard dosage prophylaxis. However, 3% of patients on high enoxaparin dosages had non-fatal major bleeding.

Original languageEnglish
JournalInternal and Emergency Medicine
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Anticoagulants
  • Coronavirus
  • Enoxaparin
  • Mortality
  • Venous thromboembolism

ASJC Scopus subject areas

  • Internal Medicine
  • Emergency Medicine

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