TY - JOUR
T1 - Increasing doses of l-sulpiride reveal dose- and spatial frequency-dependent effects of D2 selective blockade in the human electroretinogram
AU - Stanzione, P.
AU - Pierantozzi, M.
AU - Semprini, R.
AU - Tagliati, M.
AU - Traversa, R.
AU - Peppe, A.
AU - Pierelli, F.
AU - Bernardi, G.
PY - 1995
Y1 - 1995
N2 - The amplitude and phase of the second harmonic (15 Hz) of the electroretinographic responses to three different spatial frequency grating stimuli (0.25, 1 and 4 c/deg), reversed at 7.5 Hz, were studied in normal human subjects, before and 30 min after the systemic administration of three doses (0.071, 0.357 or 1.428 mg/kg) of a selective D2 blocker, l-sulpiride, to three populations of 18, 19 or 20 subjects. The effect of the drug on the pattern electroretinogram (PERG) was clearly dose-dependent, being greatest on the responses to 4 c/deg. The mean decrease in second harmonic amplitude was -13.8% after 0.071 mg/kg of l-sulpiride, -23.5% after 0.357 mg/kg and -28.5% after 1.428 mg/kg. The last two variations were significant at P <0.01 and P <0.01 respectively. These data suggest that a dose-dependent effect on the human retinal response to 4 c/deg stimuli exists, probably mediated by a coupling between l-sulpiride and D2 receptors. Lastly, our data suggest that D2 receptors may play an important role in the pathophysiology of visual dysfunction in Parkinson's disease, that has been described to be more significant at medium spatial frequency (2-5 c/deg).
AB - The amplitude and phase of the second harmonic (15 Hz) of the electroretinographic responses to three different spatial frequency grating stimuli (0.25, 1 and 4 c/deg), reversed at 7.5 Hz, were studied in normal human subjects, before and 30 min after the systemic administration of three doses (0.071, 0.357 or 1.428 mg/kg) of a selective D2 blocker, l-sulpiride, to three populations of 18, 19 or 20 subjects. The effect of the drug on the pattern electroretinogram (PERG) was clearly dose-dependent, being greatest on the responses to 4 c/deg. The mean decrease in second harmonic amplitude was -13.8% after 0.071 mg/kg of l-sulpiride, -23.5% after 0.357 mg/kg and -28.5% after 1.428 mg/kg. The last two variations were significant at P <0.01 and P <0.01 respectively. These data suggest that a dose-dependent effect on the human retinal response to 4 c/deg stimuli exists, probably mediated by a coupling between l-sulpiride and D2 receptors. Lastly, our data suggest that D2 receptors may play an important role in the pathophysiology of visual dysfunction in Parkinson's disease, that has been described to be more significant at medium spatial frequency (2-5 c/deg).
KW - Dopamine
KW - Electroretinogram
KW - Human
KW - l-Sulpiride
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=0029161573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029161573&partnerID=8YFLogxK
U2 - 10.1016/0042-6989(95)00037-Z
DO - 10.1016/0042-6989(95)00037-Z
M3 - Article
C2 - 7483307
AN - SCOPUS:0029161573
VL - 35
SP - 2659
EP - 2664
JO - Vision Research
JF - Vision Research
SN - 0042-6989
IS - 18
ER -