Increasing Rates of Perioperative Chemotherapy are Associated With Improved Survival in Men With Urothelial Bladder Cancer With Prostatic Stromal Invasion

Giuseppe Rosiello, Sophie Knipper, Carlotta Palumbo, Angela Pecoraro, Stefano Luzzago, Marina Deuker, Zhe Tian, Giorgio Gandaglia, Andrea Gallina, Francesco Montorsi, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review


Background: Our objective was to test whether the rates of perioperative chemotherapy (CHT) administration in patients with urothelial bladder cancer (UCUB) with prostatic stromal invasion (pT4a) changed over time. Moreover, we tested the effect of CHT on overall mortality (OM), as well as on cancer-specific mortality (CSM) in this patient population. Materials and Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2016), we identified 1513 men with non-metastatic UCUB with prostatic stromal invasion who underwent radical cystectomy with lymph node dissection, with or without CHT administration. Estimated annual percentage change analyses, inverse probability of treatment-weighting (IPTW), Kaplan-Meier plots, Cox regression models, and landmark analyses were performed. Results: Overall, 732 (48.4%) patients with pT4a UCUB disease underwent radical cystectomy with perioperative CHT administration between 2004 and 2016. The CHT administration rate increased from 29.0% in 2004 to 64.8% in 2016 (P < .001). In IPTW-adjusted analyses, the 5-year overall survival was 47.7% versus 39.8%, and cancer-specific survival was 53.6 versus 50.1%, for with versus without CHT administration, respectively. After multivariable and IPTW-adjusted Cox regression models, administration of CHT independently predicted lower OM (hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.52-0.73), as well as lower CSM (HR, 0.66; 95% CI, 0.55-0.80). even after 3-month landmark analyses (OM HR, 0.64; 95% CI 0.54-0.76; CSM HR, 0.70; 95% CI, 0.58-0.85). Conclusions: The use of CHT in patients with pT4a UCUB increased from low to moderate in the most contemporary era. However, based on its impressive reduction in OM, as well as in CSM, further increases in CHT administration rates should be highly encouraged in this patient population. The use of perioperative chemotherapy in patients with bladder cancer with prostatic stromal invasion is increasing over time. Its use before or after radical cystectomy results in up to 30% reduction of overall mortality and cancer-specific mortality, even in elderly patients. The importance of survival benefit owing to perioperative chemotherapy is emphasized by the known poor survival outcomes in these types of patients.

Original languageEnglish
Pages (from-to)35-44.e1
JournalClinical Genitourinary Cancer
Issue number1
Publication statusPublished - Feb 2020


  • Locally advanced disease
  • pT4a UCUB
  • Radical cystectomy
  • SEER database
  • Time trend

ASJC Scopus subject areas

  • Oncology
  • Urology


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