Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

Andrea Mengarelli; Anna Paola Iori; Raffaella Cerretti; Lorenza Cerilli; Atelda Romano; William Arcese

Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

Andrea Mengarelli, Anna Paola Iori, Raffaella Cerretti, Lorenza Cerilli, Atelda Romano, William Arcese

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2^nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

Original language	English
Pages (from-to)	782-784
Number of pages	3
Journal	Haematologica
Volume	87
Issue number	7
Publication status	Published - 2002

Keywords

Adult acute lymphoblastic leukemia
Allogeneic stem cell transplantation
Leukemia relapse
Multi-drug resistance

ASJC Scopus subject areas

Hematology

Cite this

Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy. / Mengarelli, Andrea; Iori, Anna Paola; Cerretti, Raffaella; Cerilli, Lorenza; Romano, Atelda; Arcese, William.

In: Haematologica, Vol. 87, No. 7, 2002, p. 782-784.

Research output: Contribution to journal › Article › peer-review

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AU - Mengarelli, Andrea

AU - Iori, Anna Paola

AU - Cerretti, Raffaella

AU - Cerilli, Lorenza

AU - Romano, Atelda

AU - Arcese, William

PY - 2002

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AB - From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

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KW - Allogeneic stem cell transplantation

KW - Leukemia relapse

KW - Multi-drug resistance

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ER -

Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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