Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

Andrea Mengarelli, Anna Paola Iori, Raffaella Cerretti, Lorenza Cerilli, Atelda Romano, William Arcese

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

Original languageEnglish
Pages (from-to)782-784
Number of pages3
JournalHaematologica
Volume87
Issue number7
Publication statusPublished - 2002

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Stem Cells
Transplants
Recurrence
Drug Therapy
Leukemia
Mortality

Keywords

  • Adult acute lymphoblastic leukemia
  • Allogeneic stem cell transplantation
  • Leukemia relapse
  • Multi-drug resistance

ASJC Scopus subject areas

  • Hematology

Cite this

Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy. / Mengarelli, Andrea; Iori, Anna Paola; Cerretti, Raffaella; Cerilli, Lorenza; Romano, Atelda; Arcese, William.

In: Haematologica, Vol. 87, No. 7, 2002, p. 782-784.

Research output: Contribution to journalArticle

Mengarelli, Andrea ; Iori, Anna Paola ; Cerretti, Raffaella ; Cerilli, Lorenza ; Romano, Atelda ; Arcese, William. / Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy. In: Haematologica. 2002 ; Vol. 87, No. 7. pp. 782-784.
@article{bc496e5bb37343d6ad3bfbf1270d12e9,
title = "Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy",
abstract = "From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.",
keywords = "Adult acute lymphoblastic leukemia, Allogeneic stem cell transplantation, Leukemia relapse, Multi-drug resistance",
author = "Andrea Mengarelli and Iori, {Anna Paola} and Raffaella Cerretti and Lorenza Cerilli and Atelda Romano and William Arcese",
year = "2002",
language = "English",
volume = "87",
pages = "782--784",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "7",

}

TY - JOUR

T1 - Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

AU - Mengarelli, Andrea

AU - Iori, Anna Paola

AU - Cerretti, Raffaella

AU - Cerilli, Lorenza

AU - Romano, Atelda

AU - Arcese, William

PY - 2002

Y1 - 2002

N2 - From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

AB - From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

KW - Adult acute lymphoblastic leukemia

KW - Allogeneic stem cell transplantation

KW - Leukemia relapse

KW - Multi-drug resistance

UR - http://www.scopus.com/inward/record.url?scp=0036070536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036070536&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 782

EP - 784

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 7

ER -