Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in ≥ 2nd complete remission induced by highly intensive chemotherapy

Andrea Mengarelli, Anna Paola Iori, Raffaella Cerretti, Lorenza Cerilli, Atelda Romano, William Arcese

Research output: Contribution to journalArticle

Abstract

From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in ≥2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.

Original languageEnglish
Pages (from-to)782-784
Number of pages3
JournalHaematologica
Volume87
Issue number7
Publication statusPublished - 2002

    Fingerprint

Keywords

  • Adult acute lymphoblastic leukemia
  • Allogeneic stem cell transplantation
  • Leukemia relapse
  • Multi-drug resistance

ASJC Scopus subject areas

  • Hematology

Cite this