Increasing the antibacterial effect of lysozyme by immobilization on multi-walled carbon nanotubes

Daniele Merli; Monica Ugonino; Antonella Profumo; Maurizio Fagnoni; Eliana Quartarone; Piercarlo Mustarelli; Livia Visai; Marco S. Grandi; Pietro Galinetto; Patrizia Canton

doi:10.1166/jnn.2011.3758

Increasing the antibacterial effect of lysozyme by immobilization on multi-walled carbon nanotubes

Daniele Merli, Monica Ugonino, Antonella Profumo, Maurizio Fagnoni, Eliana Quartarone, Piercarlo Mustarelli, Livia Visai, Marco S. Grandi, Pietro Galinetto, Patrizia Canton

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

We report a facile strategy to obtain multiwalled carbon nanotubes (MWCNTs) functionalized with covalently bonded lysozyme. The functionalization procedure has been investigated by means of several techniques, including thermogravimetry, Raman spectroscopy, transmission electron microscopy, and cyclic voltammetry. A functionalization of about 1 lysozyme molecule every 4000 carbon atoms is obtained. The modified lysozyme-CNTs nanocomposite shows a significant increase of the antibacterial activity towards the Gram-positive S. aureus if compared with lysozyme in solution.

Original language	English
Pages (from-to)	3100-3106
Number of pages	7
Journal	Journal of Nanoscience and Nanotechnology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1166/jnn.2011.3758
Publication status	Published - 2011

Keywords

Antibacterial Activity
Carbon Nanotube
Covalent Binding
Lysozyme
Nanomedicine

ASJC Scopus subject areas

Condensed Matter Physics
Chemistry(all)
Materials Science(all)
Bioengineering
Biomedical Engineering

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abstract = "We report a facile strategy to obtain multiwalled carbon nanotubes (MWCNTs) functionalized with covalently bonded lysozyme. The functionalization procedure has been investigated by means of several techniques, including thermogravimetry, Raman spectroscopy, transmission electron microscopy, and cyclic voltammetry. A functionalization of about 1 lysozyme molecule every 4000 carbon atoms is obtained. The modified lysozyme-CNTs nanocomposite shows a significant increase of the antibacterial activity towards the Gram-positive S. aureus if compared with lysozyme in solution.",

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AU - Merli, Daniele

AU - Ugonino, Monica

AU - Profumo, Antonella

AU - Fagnoni, Maurizio

AU - Quartarone, Eliana

AU - Mustarelli, Piercarlo

AU - Visai, Livia

AU - Grandi, Marco S.

AU - Galinetto, Pietro

AU - Canton, Patrizia

PY - 2011

Y1 - 2011

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KW - Carbon Nanotube

KW - Covalent Binding

KW - Lysozyme

KW - Nanomedicine

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Increasing the antibacterial effect of lysozyme by immobilization on multi-walled carbon nanotubes

Abstract

Keywords

ASJC Scopus subject areas

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