Increasing the antibacterial effect of lysozyme by immobilization on multi-walled carbon nanotubes

Daniele Merli, Monica Ugonino, Antonella Profumo, Maurizio Fagnoni, Eliana Quartarone, Piercarlo Mustarelli, Livia Visai, Marco S. Grandi, Pietro Galinetto, Patrizia Canton

Research output: Contribution to journalArticlepeer-review

Abstract

We report a facile strategy to obtain multiwalled carbon nanotubes (MWCNTs) functionalized with covalently bonded lysozyme. The functionalization procedure has been investigated by means of several techniques, including thermogravimetry, Raman spectroscopy, transmission electron microscopy, and cyclic voltammetry. A functionalization of about 1 lysozyme molecule every 4000 carbon atoms is obtained. The modified lysozyme-CNTs nanocomposite shows a significant increase of the antibacterial activity towards the Gram-positive S. aureus if compared with lysozyme in solution.

Original languageEnglish
Pages (from-to)3100-3106
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume11
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • Antibacterial Activity
  • Carbon Nanotube
  • Covalent Binding
  • Lysozyme
  • Nanomedicine

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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