Incremental prognostic value of serum levels of troponin T and C- reactive protein on admission in patients with unstable angina pectoris

A. G. Rebuzzi, G. Quaranta, G. Liuzzo, G. Caligiuri, G. A. Lanza, J. R. Gallimore, R. L. Grillo, D. Cianflone, L. M. Biasucci, A. Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Management of unstable angina is largely determined by symptoms, yet some symptomatic patients stabilize, whereas others develop myocardial infarction after waning of symptoms. Therefore, markers of short-term risk, available on admission, are needed. The value of 4 prognostic indicators available on admission (pain in the last 24 hours, electrocardiogram [ECG], troponin T, and C-reactive protein [CRP]), and of Holter monitoring available during the subsequent 24 hours was analyzed in 102 patients with Braunwald class IIIB unstable angina hospitalized in 4 centers. The patients were divided into 3 groups: group 1, 27 with pain during the last 24 hours and ischemic electrocardiographic changes; group 2, 45 with pain or electrocardiographic changes; group 3, 30 with neither pain nor electrocardiographic changes. Troponin T, CRP, ECG on admission, and Holter monitoring were analyzed blindly in the core laboratory. Fifteen patients developed myocardial infarction: 22% in group 1, 13% in group 2, and 10% in group 3. Twenty-eight patients underwent revascularization: 37% in group 1, 35% in group 2, and 7% in group 2 (p

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalThe American Journal of Cardiology
Volume82
Issue number6
DOIs
Publication statusPublished - Sep 15 1998

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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