Incremental prognostic value of thallium reinjection after stress- redistribution imaging in patients with previous myocardial infarction and left ventricular dysfunction

Mario Petretta, Alberto Cuocolo, Domenico Bonaduce, Emanuele Nicolai, Stefania Cardei, Sabino Berardino, Angiolino Ianniciello, Claudio Apicella, Valter Bianchi, Marco Salvatore

Research output: Contribution to journalArticle

Abstract

This study evaluated the incremental prognostic value of 201Tl reinjection imaging over clinical, exercise and thallium stress- redistribution data in patients with previous myocardial infarction and left ventricular dysfunction. Methods: Thallium-201 reinjection after stress- redistribution SPECT was performed in 104 consecutive patients with a first Q-wave myocardial infarction (>8 wk) and left ventricular ejection fraction ≤40%. Follow-up data (mean 22 mo) were available for 98 patients; 16 patients underwent early revascularization procedures within 3 mo after exercise testing and were not considered for the analysis. Results: During follow-up there were 13 hard events (cardiac death and myocardial infarction) and 11 soft events (coronary revascularization procedures >3 mo after thallium imaging). With multivariate Cox regression analysis, the sum of defects at stress redistribution imaging that were reversible or moderate irreversible after reinjection was a powerful predictor of subsequent events. The addition of thallium reinjection imaging data significantly improved the prognostic power of clinical, exercise and stress-redistribution data for the occurrence of hard events (p <0.01). Conclusion: In patients with previous myocardial infarction and left ventricular dysfunction, thallium reinjection imaging provides incremental prognostic information over those obtained from conventional stress-redistribution imaging.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalJournal of Nuclear Medicine
Volume38
Issue number2
Publication statusPublished - Feb 1997

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Thallium
Left Ventricular Dysfunction
Myocardial Infarction
Exercise
Single-Photon Emission-Computed Tomography
Stroke Volume
Regression Analysis

Keywords

  • left ventricular dysfunction
  • myocardial infarction
  • thallium reinjection imaging
  • viable myocardium

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Incremental prognostic value of thallium reinjection after stress- redistribution imaging in patients with previous myocardial infarction and left ventricular dysfunction. / Petretta, Mario; Cuocolo, Alberto; Bonaduce, Domenico; Nicolai, Emanuele; Cardei, Stefania; Berardino, Sabino; Ianniciello, Angiolino; Apicella, Claudio; Bianchi, Valter; Salvatore, Marco.

In: Journal of Nuclear Medicine, Vol. 38, No. 2, 02.1997, p. 195-200.

Research output: Contribution to journalArticle

Petretta, Mario ; Cuocolo, Alberto ; Bonaduce, Domenico ; Nicolai, Emanuele ; Cardei, Stefania ; Berardino, Sabino ; Ianniciello, Angiolino ; Apicella, Claudio ; Bianchi, Valter ; Salvatore, Marco. / Incremental prognostic value of thallium reinjection after stress- redistribution imaging in patients with previous myocardial infarction and left ventricular dysfunction. In: Journal of Nuclear Medicine. 1997 ; Vol. 38, No. 2. pp. 195-200.
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AU - Berardino, Sabino

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