Incretin-based therapies in type 2 diabetes: A review of clinical results

Emanuele Bosi; Pietro Lucotti; Emanuela Setola; Lucilla Monti; Pier Marco Piatti

doi:10.1016/j.diabres.2008.10.003

Incretin-based therapies in type 2 diabetes: A review of clinical results

Emanuele Bosi, Pietro Lucotti, Emanuela Setola, Lucilla Monti, Pier Marco Piatti

Research output: Contribution to journal › Article › peer-review

Abstract

GLP-1 analogues (incretin mimetics) and DPP-4 inhibitors (incretin enhancers) represent new classes of anti-diabetic agents for the treatment of type 2 diabetes. The efficacy and safety of the incretin mimetic exenatide and of the DPP-4 inhibitors, sitagliptin and vildagliptin, have been clearly demonstrated by a very large number of clinical trials. Efficacy was demonstrated in terms of reduction of HbA1c, fasting and postprandial glucose. Moreover, exenatide showed a favourable effect on weight, while DPP-4 inhibitors were neutral with respect to this outcome. The low rate of hypoglycemic events seen in all studies confirms the glucose dependent action of incretins.

Original language	English
Journal	Diabetes Research and Clinical Practice
Volume	82
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/j.diabres.2008.10.003
Publication status	Published - Dec 15 2008

Keywords

Diabetes mellitus
DPP-4 inhibitors
Exenatide
GLP-1 analogues
Sitagliptin
Vidagliptin

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Internal Medicine
Endocrinology

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10.1016/j.diabres.2008.10.003

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abstract = "GLP-1 analogues (incretin mimetics) and DPP-4 inhibitors (incretin enhancers) represent new classes of anti-diabetic agents for the treatment of type 2 diabetes. The efficacy and safety of the incretin mimetic exenatide and of the DPP-4 inhibitors, sitagliptin and vildagliptin, have been clearly demonstrated by a very large number of clinical trials. Efficacy was demonstrated in terms of reduction of HbA1c, fasting and postprandial glucose. Moreover, exenatide showed a favourable effect on weight, while DPP-4 inhibitors were neutral with respect to this outcome. The low rate of hypoglycemic events seen in all studies confirms the glucose dependent action of incretins.",

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AU - Lucotti, Pietro

AU - Setola, Emanuela

AU - Monti, Lucilla

AU - Piatti, Pier Marco

PY - 2008/12/15

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Incretin-based therapies in type 2 diabetes: A review of clinical results

Abstract

Keywords

ASJC Scopus subject areas

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