Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures

Tiziana Franchin, Maria G. Tana, Vittorio Cannata, Sergio Cerutti, Anna M. Bianchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we present a method for classifying fMRI independent components (ICs) by using an optimized algorithm for the individuation of noisy signals from sources of interest. The method was applied to estimate brain activations from combined EEG-fMRI data for the exploration of epilepsy. Spatial ICA was performed using the above-mentioned optimized algorithm and other three popular algorithms. ICs were sorted considering the value: of the coefficients of determination R2, obtained from the multiple regression analysis with morphometric maps of cerebral matter; of the kurtosis, which features the signal energy. The validation of the method was performed comparing the brain activations obtained with those resulted using the General Linear Model (GLM). The ICA-derived activations in different datasets comprised subareas of the GLM-revealed activations, even if the volume and the shape of activated areas do not correspond exactly. The method proposed also detects additional negative regions implicated in a default mode of brain activity, and not clearly identified by GLM. Compared with a traditional GLM approach, the ICA one provides a flexible way to analyze fMRI data that reduces the assumptions placed upon the hemodynamic response of the brain and the temporal constrains.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages6011-6014
Number of pages4
DOIs
Publication statusPublished - 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
Duration: Jul 3 2013Jul 7 2013

Other

Other2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
CountryJapan
CityOsaka
Period7/3/137/7/13

Fingerprint

Independent component analysis
Electroencephalography
Linear Models
Epilepsy
Brain
Chemical activation
Magnetic Resonance Imaging
Individuation
Hemodynamics
Regression analysis
Regression Analysis

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Franchin, T., Tana, M. G., Cannata, V., Cerutti, S., & Bianchi, A. M. (2013). Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 6011-6014). [6610922] https://doi.org/10.1109/EMBC.2013.6610922

Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures. / Franchin, Tiziana; Tana, Maria G.; Cannata, Vittorio; Cerutti, Sergio; Bianchi, Anna M.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 6011-6014 6610922.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Franchin, T, Tana, MG, Cannata, V, Cerutti, S & Bianchi, AM 2013, Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6610922, pp. 6011-6014, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 7/3/13. https://doi.org/10.1109/EMBC.2013.6610922
Franchin T, Tana MG, Cannata V, Cerutti S, Bianchi AM. Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. p. 6011-6014. 6610922 https://doi.org/10.1109/EMBC.2013.6610922
Franchin, Tiziana ; Tana, Maria G. ; Cannata, Vittorio ; Cerutti, Sergio ; Bianchi, Anna M. / Independent Component Analysis of EEG-fMRI data for studying epilepsy and epileptic seizures. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2013. pp. 6011-6014
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