TY - JOUR
T1 - Independent correlates of urinary albumin excretion within the normoalbuminuric range in patients with type 2 diabetes
T2 - The Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicentre Study
AU - Penno, Giuseppe
AU - Solini, Anna
AU - Zoppini, Giacomo
AU - Fondelli, Cecilia
AU - Trevisan, Roberto
AU - Vedovato, Monica
AU - Cavalot, Franco
AU - Gruden, Gabriella
AU - Lamacchia, Olga
AU - Laviola, Luigi
AU - Orsi, Emanuela
AU - Pugliese, Giuseppe
PY - 2015/10/22
Y1 - 2015/10/22
N2 - Aims: Within the normoalbuminuric range, low albuminuria (LA, 10–29 mg/24 h) is associated with higher adverse cardiovascular and renal outcomes than normal albuminuria (NA, 1c, triglycerides, and blood pressure (BP), use of anti-hyperglycaemic and anti-hypertensive drugs, and prevalence of metabolic syndrome, retinopathy, chronic kidney disease, any cardiovascular disease, myocardial infarction, and coronary and peripheral events. Men with LA were also more frequently current or former smokers and had higher body mass index, waist circumference, and non-HDL cholesterol. Independent correlates of LA were age (OR 1.018), family history of hypertension (OR 1.321), smoking status (former, OR 1.158; current, OR 1.237), HbA1c (OR 1.062), waist circumference (OR 1.050), triglycerides (OR 1.001), and diastolic BP (OR 1.014), together with use of anti-hyperglycaemic and anti-hypertensive agents. Conclusions: Several risk factors are associated with increased albuminuria within the normoalbuminuric range. As most of these factors are potentially modifiable, treating them aggressively might reduce the excess risk associated with LA. Trial registration: NCT00715481; www.ClinicalTrials.gov.
AB - Aims: Within the normoalbuminuric range, low albuminuria (LA, 10–29 mg/24 h) is associated with higher adverse cardiovascular and renal outcomes than normal albuminuria (NA, 1c, triglycerides, and blood pressure (BP), use of anti-hyperglycaemic and anti-hypertensive drugs, and prevalence of metabolic syndrome, retinopathy, chronic kidney disease, any cardiovascular disease, myocardial infarction, and coronary and peripheral events. Men with LA were also more frequently current or former smokers and had higher body mass index, waist circumference, and non-HDL cholesterol. Independent correlates of LA were age (OR 1.018), family history of hypertension (OR 1.321), smoking status (former, OR 1.158; current, OR 1.237), HbA1c (OR 1.062), waist circumference (OR 1.050), triglycerides (OR 1.001), and diastolic BP (OR 1.014), together with use of anti-hyperglycaemic and anti-hypertensive agents. Conclusions: Several risk factors are associated with increased albuminuria within the normoalbuminuric range. As most of these factors are potentially modifiable, treating them aggressively might reduce the excess risk associated with LA. Trial registration: NCT00715481; www.ClinicalTrials.gov.
KW - Albumin excretion rate
KW - Chronic kidney disease
KW - Diabetic retinopathy
KW - eGFR
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84941934121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941934121&partnerID=8YFLogxK
U2 - 10.1007/s00592-015-0789-x
DO - 10.1007/s00592-015-0789-x
M3 - Article
AN - SCOPUS:84941934121
VL - 52
SP - 971
EP - 981
JO - Acta Diabetologica
JF - Acta Diabetologica
SN - 0940-5429
IS - 5
ER -