Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma

G. Puppa, P. Maisonneuve, A. Sonzogni, M. Masullo, A. Chiappa, M. Valerio, M. G. Zampino, I. Franceschetti, P. Capelli, M. Chilosi, F. Menestrina, G. Viale, G. Pelosi

Research output: Contribution to journalArticlepeer-review

Abstract

Fascin, an actin-bundling protein involved in cell motility, has been shown to be upregulated in several types of carcinomas. In this study, we investigated the expression of fascin in 228 advanced colonic adenocarcinoma patients with a long follow-up. Fascin expression was compared with several clinicopathologic parameters and survival. Overall, fascin immunoreactivity was detected in 162 (71%) tumours with a prevalence for right-sided tumours (P

Original languageEnglish
Pages (from-to)1118-1126
Number of pages9
JournalBritish Journal of Cancer
Volume96
Issue number7
DOIs
Publication statusPublished - Apr 10 2007

Keywords

  • Colorectal cancer
  • Fascin
  • Immunohistochemistry
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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