Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy

Andrea Rossi, Frank L. Dini, Pompilio Faggiano, Eustachio Agricola, Mariantonietta Cicoira, Silvia Frattini, Anca Simioniuc, Mariangela Gullace, Stefano Ghio, Maurice Enriquez-Sarano, Pier Luigi Temporelli

Research output: Contribution to journalArticle


Background: Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used. Objective: To evaluate the prognostic value of FMR in patients with HF. Methods and results: Patients with HF due to ischaemic and non-ischaemic dilated cardiomyopathy (DCM) were retrospectively recruited. The clinical end point was a composite of all-cause mortality and hospitalisation for worsening HF. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm 2 or RV >30 ml or VC >0.4 cm. Restrictive mitral filling pattern (RMP) was defined as E-wave deceleration time

Original languageEnglish
Pages (from-to)1675-1680
Number of pages6
Issue number20
Publication statusPublished - Oct 2011


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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