Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy

Andrea Rossi, Frank L. Dini, Pompilio Faggiano, Eustachio Agricola, Mariantonietta Cicoira, Silvia Frattini, Anca Simioniuc, Mariangela Gullace, Stefano Ghio, Maurice Enriquez-Sarano, Pier Luigi Temporelli

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Background: Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used. Objective: To evaluate the prognostic value of FMR in patients with HF. Methods and results: Patients with HF due to ischaemic and non-ischaemic dilated cardiomyopathy (DCM) were retrospectively recruited. The clinical end point was a composite of all-cause mortality and hospitalisation for worsening HF. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm 2 or RV >30 ml or VC >0.4 cm. Restrictive mitral filling pattern (RMP) was defined as E-wave deceleration time

Original languageEnglish
Pages (from-to)1675-1680
Number of pages6
JournalHeart
Volume97
Issue number20
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Dilated Cardiomyopathy
Mitral Valve Insufficiency
Heart Failure
Deceleration
Sample Size
Hospitalization
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. / Rossi, Andrea; Dini, Frank L.; Faggiano, Pompilio; Agricola, Eustachio; Cicoira, Mariantonietta; Frattini, Silvia; Simioniuc, Anca; Gullace, Mariangela; Ghio, Stefano; Enriquez-Sarano, Maurice; Temporelli, Pier Luigi.

In: Heart, Vol. 97, No. 20, 10.2011, p. 1675-1680.

Research output: Contribution to journalArticle

Rossi, Andrea ; Dini, Frank L. ; Faggiano, Pompilio ; Agricola, Eustachio ; Cicoira, Mariantonietta ; Frattini, Silvia ; Simioniuc, Anca ; Gullace, Mariangela ; Ghio, Stefano ; Enriquez-Sarano, Maurice ; Temporelli, Pier Luigi. / Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. In: Heart. 2011 ; Vol. 97, No. 20. pp. 1675-1680.
@article{21a30264e63641ff842b3ffac610c7f4,
title = "Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy",
abstract = "Background: Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used. Objective: To evaluate the prognostic value of FMR in patients with HF. Methods and results: Patients with HF due to ischaemic and non-ischaemic dilated cardiomyopathy (DCM) were retrospectively recruited. The clinical end point was a composite of all-cause mortality and hospitalisation for worsening HF. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm 2 or RV >30 ml or VC >0.4 cm. Restrictive mitral filling pattern (RMP) was defined as E-wave deceleration time",
author = "Andrea Rossi and Dini, {Frank L.} and Pompilio Faggiano and Eustachio Agricola and Mariantonietta Cicoira and Silvia Frattini and Anca Simioniuc and Mariangela Gullace and Stefano Ghio and Maurice Enriquez-Sarano and Temporelli, {Pier Luigi}",
year = "2011",
month = "10",
doi = "10.1136/hrt.2011.225789",
language = "English",
volume = "97",
pages = "1675--1680",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "20",

}

TY - JOUR

T1 - Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy

AU - Rossi, Andrea

AU - Dini, Frank L.

AU - Faggiano, Pompilio

AU - Agricola, Eustachio

AU - Cicoira, Mariantonietta

AU - Frattini, Silvia

AU - Simioniuc, Anca

AU - Gullace, Mariangela

AU - Ghio, Stefano

AU - Enriquez-Sarano, Maurice

AU - Temporelli, Pier Luigi

PY - 2011/10

Y1 - 2011/10

N2 - Background: Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used. Objective: To evaluate the prognostic value of FMR in patients with HF. Methods and results: Patients with HF due to ischaemic and non-ischaemic dilated cardiomyopathy (DCM) were retrospectively recruited. The clinical end point was a composite of all-cause mortality and hospitalisation for worsening HF. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm 2 or RV >30 ml or VC >0.4 cm. Restrictive mitral filling pattern (RMP) was defined as E-wave deceleration time

AB - Background: Functional mitral regurgitation (FMR) is a common finding in patients with heart failure (HF), but its effect on outcome is still uncertain, mainly because in previous studies sample sizes were relatively small and semiquantitative methods for FMR grading were used. Objective: To evaluate the prognostic value of FMR in patients with HF. Methods and results: Patients with HF due to ischaemic and non-ischaemic dilated cardiomyopathy (DCM) were retrospectively recruited. The clinical end point was a composite of all-cause mortality and hospitalisation for worsening HF. FMR was quantitatively determined by measuring vena contracta (VC) or effective regurgitant orifice (ERO) or regurgitant volume (RV). Severe FMR was defined as ERO >0.2 cm 2 or RV >30 ml or VC >0.4 cm. Restrictive mitral filling pattern (RMP) was defined as E-wave deceleration time

UR - http://www.scopus.com/inward/record.url?scp=80053186563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053186563&partnerID=8YFLogxK

U2 - 10.1136/hrt.2011.225789

DO - 10.1136/hrt.2011.225789

M3 - Article

C2 - 21807656

AN - SCOPUS:80053186563

VL - 97

SP - 1675

EP - 1680

JO - Heart

JF - Heart

SN - 1355-6037

IS - 20

ER -