Independent validation of a model predicting the need for packed red blood cell transfusion at liver transplantation

Luc Massicotte, Umberto Capitanio, Danielle Beaulieu, Jean Denis Roy, André Roy, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES. Orthotopic liver transplantation (OLT) may be associated with major blood loss and equally considerable transfusion requirements. We had developed previously a model capable of predicting the probability of packed red blood cell (PRBC) transfusion. We tested the ability of that model in predicting the need for PRBC transfusion after its conversion into the nomogram format, which represents a friendly tool to be used. Moreover, the nomogram was validated in an independent cohort of 109 prospectively gathered OLTs. MATERIALS AND METHODS. A total of 515 OLTs were performed by a group of 17 anesthesiologists and 7 hepatobiliary surgeons. The initial series of 406 OLTs were used for model development. The remaining 109 OLTs were used as an independent validation cohort. Logistic regression analyses addressed the relationship between the three previously identified predictors of the likelihood of PRBC transfusion and the actual rate of PRBC transfusion. The predictors consisted of plasma transfusion status, phlebotomy, and immediate preoperative hemoglobin value. The regression coefficients from the multivariable logistic regression model that included all three predictors were used to develop a nomogram predicting the individual probability of PRBC transfusion. RESULTS. In univariable models, transfusion of plasma (odds ratio [OR] 15.0, P

Original languageEnglish
Pages (from-to)386-391
Number of pages6
JournalTransplantation
Volume88
Issue number3
DOIs
Publication statusPublished - Aug 15 2009

Keywords

  • Liver transplantation
  • Prediction
  • Transfusion

ASJC Scopus subject areas

  • Transplantation

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