Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids

Giuseppe Pelosi, Felice Pasini, Filippo Fraggetta, Ugo Pastorino, Antonio Iannucci, Patrick Maisonneuve, Gianluigi Arrigoni, Giovanni De Manzoni, Enrica Bresaola, Giuseppe Viale

Research output: Contribution to journalArticle

Abstract

Immunoreactivity for fascin, an actin-bundling protein related to cell motility, has been reported in breast, ovary, pancreas, skin, and non-small cell carcinomas, and associated with more advanced disease stage and poorer prognosis. Data on pulmonary neuroendocrine (NE) tumors, however, are lacking. We evaluated the expression of fascin by immunohistochemistry - using two different monoclonal antibodies - in surgical specimens of pulmonary NE tumors of all the diverse histological types from 128 consecutive patients recruited between 1987 and 2001, and investigated its relationship with the presence of lymph node metastases. Overall, fascin immunoreactivity was detected in 5% of 38 typical carcinoids (TC), 35% of 23 atypical carcinoids (AC), 83% of 40 large-cell neuroendocrine carcinomas (LCNEC), and 100% of 27 small-cell lung carcinomas (SCLC) (P5%) (P=0.020), and with either down-regulation or altered subcellular compartmentalization of E-cadherin (P

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalLung Cancer
Volume42
Issue number2
DOIs
Publication statusPublished - Nov 1 2003

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Keywords

  • Carcinoid
  • Fascin
  • Immunohistochemistry
  • Lung
  • Neuroendocrine
  • Tumors

ASJC Scopus subject areas

  • Oncology

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