Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019: Bone Marrow Transplantation

R.F. Duarte, M. Labopin, P. Bader, G.W. Basak, C. Bonini, C. Chabannon, S. Corbacioglu, P. Dreger, C. Dufour, A.R. Gennery, J. Kuball, A.C. Lankester, F. Lanza, S. Montoto, A. Nagler, R. Peffault de Latour, J.A. Snowden, J. Styczynski, I. Yakoub-Agha, N. KrögerM. Mohty, for the European Society for Blood and Marrow Transplantation (EBMT)

Research output: Contribution to journalArticlepeer-review

Abstract

This is the seventh special EBMT report on the indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on transplant indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered together with the risk of the disease, the risk of the transplant procedure and the results of non-transplant strategies. In over two decades since the first report, the EBMT indications manuscripts have incorporated changes in transplant practice coming from scientific and technical developments in the field. In this same period, the establishment of JACIE accreditation has promoted high quality and led to improved outcomes of patient and donor care and laboratory performance in transplantation and cellular therapy. An updated report with operating definitions, revised indications and an additional set of data with overall survival at 1 year and non-relapse mortality at day 100 after transplant in the commonest standard-of-care indications is presented. Additional efforts are currently underway to enable EBMT member centres to benchmark their risk-adapted outcomes as part of the Registry upgrade Project 2020 against national and/or international outcome data. © 2019, Springer Nature Limited.
Original languageEnglish
Pages (from-to)1525-1552
Number of pages28
JournalBone Marrow Transplant.
Volume54
Issue number10
DOIs
Publication statusPublished - 2020

Keywords

  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • AL amyloidosis
  • Albers Schoenberg disease
  • allogeneic hematopoietic stem cell transplantation
  • aplastic anemia
  • Article
  • autoimmune disease
  • autologous hematopoietic stem cell transplantation
  • bone marrow depression
  • chronic lymphatic leukemia
  • chronic myeloid leukemia
  • diffuse large B cell lymphoma
  • follicular lymphoma
  • hematologic disease
  • hematopoietic stem cell transplantation
  • hemoglobinopathy
  • HLA matching
  • Hodgkin disease
  • human
  • immune deficiency
  • immunopathology
  • juvenile myelomonocytic leukemia
  • mantle cell lymphoma
  • matched related donor
  • matched unrelated donor
  • metabolic disorder
  • mismatched unrelated donor
  • multiple myeloma
  • myelodysplastic syndrome
  • myeloproliferative disorder
  • overall survival
  • paroxysmal nocturnal hemoglobinuria
  • priority journal
  • severe combined immunodeficiency
  • solid malignant neoplasm
  • T cell lymphoma
  • Waldenstroem macroglobulinemia
  • Europe
  • history
  • neoplasm
  • procedures
  • transplantation conditioning
  • Hematologic Diseases
  • Hematopoietic Stem Cell Transplantation
  • History, 21st Century
  • Humans
  • Immune System Diseases
  • Neoplasms
  • Transplantation Conditioning

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