Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: A consensus project of the EBMT-lymphoma working party

Silvia Montoto, Paolo Corradini, Martin Dreyling, Michele Ghielmini, Eva Kimby, Armando López-Guillermo, Stephen Mackinnon, Robert E. Marcus, Gilles Salles, Harry C. Schouten, Anna Sureda, Peter Dreger

Research output: Contribution to journalArticle

Abstract

The aim of this project was to define indications for hematopoietic stem cell transplantation in follicular lymphoma in Europe. In the absence of evidence-based data, a RAND-modified Delphi procedure was used by an expert panel. After pre-defining statements, these were individually/anonymously scored by each participant using a 9-point scale. Consensus was reached that: 1) high-dose therapy with autologous stem cell rescue is not an appropriate option to consolidate first remission in patients responding to immuno-chemotherapy outside clinical trials; 2) in patients with first chemo-sensitive relapse, high-dose therapy with autologous stem cell rescue is an appropriate option to consolidate remission, especially in patients with a short response after immuno-chemotherapy or with high-risk FLIPI; 3) high-dose therapy with autologous stem cell rescue is also appropriate in second/subsequent chemo-sensitive relapses; 4) allotransplant (preferably a reduced intensity conditioning-allotransplant) should be considered at relapse after high-dose therapy with autologous stem cell rescue. No consensus was reached on the role of high-dose therapy with autologous stem cell rescue in low-risk first relapse, or on when an allotransplant should be preferred over high-dose therapy with autologous stem cell rescue. In the absence of evidence-based data, the consensus method used was a valuable tool to define indications for hematopoietic stem cell transplant in follicular lymphoma.

Original languageEnglish
Pages (from-to)1014-1021
Number of pages8
JournalHaematologica
Volume98
Issue number7
DOIs
Publication statusPublished - Jul 2013

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: A consensus project of the EBMT-lymphoma working party'. Together they form a unique fingerprint.

  • Cite this

    Montoto, S., Corradini, P., Dreyling, M., Ghielmini, M., Kimby, E., López-Guillermo, A., Mackinnon, S., Marcus, R. E., Salles, G., Schouten, H. C., Sureda, A., & Dreger, P. (2013). Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: A consensus project of the EBMT-lymphoma working party. Haematologica, 98(7), 1014-1021. https://doi.org/10.3324/haematol.2013.084723