The main currently accepted indication for pancreas transplantation is type 1 diabetes with accompanying kidney transplantation for end-stage renal failure. The pancreas transplants mostly have been performed simultaneously with or after the kidney transplants, although in qualified surgical centers, pancreas transplants alone have been frequently performed. Furthermore, cases of a combined kidney and segmental pancreas transplant from a living donor also exist. Today, kidney-pancreas transplantation must be proposed to prolong patient survival and to improve quality of life and decrease secondary complications from diabetes. In view of the recently achieved results in terms of cardiac function and autonomic neuropathy, pancreas transplantation could be offered in nonselected patients who are prone to congestive heart failure. Pancreas transplantation alone should be considered a therapy for nonuremic patients with brittle diabetes, associated with clinical and emotional problems with exogenous insulin therapy, which are so severe as to be incapacitating.
ASJC Scopus subject areas
- Immunology and Allergy