Indicazione al trattamento medico con steroidi e lazzaroidi nel paziente con ESA.

Translated title of the contribution: Indications for steroid and tirilazad treatment in patients with subarachnoid hemorrhage

C. Tommasino, P. Picozzi

Research output: Contribution to journalArticlepeer-review

Abstract

Tirilazad mesylate, a nonglucocorticoid 21-aminosteroid, has been used in two randomized, double-blind, vehicle-controlled trials in Europe, Australia, New Zealand, and in North America in patients with aneurysmal subarachnoid hemorrhage. The first trial has been concluded, enrolled 1023 patients, and demonstrated a dramatic reduction in mortality from 27% to 3% (p = 0.01) in males receiving 6 mg/kg/day tirilazad for 10 days, when compared to vehicle-treated patients. There was also a less incidence of symptomatic vasospasm, and the frequency of hypertensive-hypervolemic-hemodilution therapy was significantly reduced. The reduction in mortality rate was remarkable, however the benefits of treatment with tirilazad were predominantly shown in men rather than in women. This clinical trial suggest that tirilazad mesylate, at a dosage of 6 mg/kg/day, improves overall outcome in aneurysmal subarachnoid hemorrhage patients. Further data from the North America trial and the trial in women receiving higher doses of tirilazad are still pending.

Translated title of the contributionIndications for steroid and tirilazad treatment in patients with subarachnoid hemorrhage
Original languageItalian
Pages (from-to)225-227
Number of pages3
JournalMinerva Anestesiologica
Volume64
Issue number5
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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