The relation between emotional stress and stimulation of the sympathetic nervous system was assessed by digital plethysmographic estimation of the peripheral cutaneous vascular flow. Heart rate and arterial blood-pressure were also measured. The clinical trial was carried out in 22 preoperative patients, half of whom were pre-medicated with Cl-DMDZ (19.25 μg/kg perorally) and the others with placebo. Plethysmography showed persistent vasoconstriction after placebo and progressive vasodilatation after benzodiazepine administration. No significant variations in heart rate and blood pressure were found. The results indicate that premedication with Cl-DMDZ, by preventing the neurosympathetic peripheral vasoconstriction typically related to the anxiety state, induces directly or indirectly normal vascularization of the tone in the limbs.
|Translated title of the contribution||Indirect assessment of pre-operative emotional stress by digital plethysmography before and after pre-medication with chlordemethyl-diazepam|
|Number of pages||6|
|Journal||Acta Anaesthesiologica Italica|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine