TY - JOUR
T1 - Individual patient meta-analysis of exercise training effects on systemic brain natriuretic peptide expression in heart failure
AU - Smart, N. A.
AU - Meyer, T.
AU - Butterfield, J. A.
AU - Faddy, S. C.
AU - Passino, C.
AU - Malfatto, G.
AU - Jonsdottir, S.
AU - Sarullo, F.
AU - Wisloff, U.
AU - Vigorito, C.
AU - Giallauria, F.
PY - 2012/6
Y1 - 2012/6
N2 - Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP. Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO2; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO2. Design: Individual patient meta-analysis. Methods: A systematic search was conducted of Medline (Ovid), Embase.com, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO2. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures. Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p <0.0001), NT-pro-BNP (-37.4%, p = <0.0001), and peak VO2 (17.8%, p <0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r = -0.31, p <0.0001) and NT-pro-BNP (r = -0.22, p <0.0001) were correlated with peak VO2 change. Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO2 in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO2 changes.
AB - Background: Brain natriuretic peptide (BNP) predicts exercise performance and exercise training may modulate BNP and its N-terminal portion (NT-pro-BNP), we therefore conducted an individual patient analysis of exercise training effects on BNP and NT-pro-BNP. Aims: To use an individual patient meta-analysis to relate changes in BNP, NT-pro-BNP, and peak VO2; to link these changes to volume parameters of exercise training programmes (intensity etc.); and to identify patient characteristics likely to lead to greater improvements in BNP, NT-pro-BNP, and peak VO2. Design: Individual patient meta-analysis. Methods: A systematic search was conducted of Medline (Ovid), Embase.com, Cochrane Central Register of Controlled Trials, and CINAHL (until July 2008) to identify randomized controlled trials of aerobic and/or resistance exercise training in systolic heart failure patients measuring BNP and/or NT-pro-BNP. Primary outcome measures were change in BNP, NT-pro-BNP, and peak VO2. Subanalyses were conducted to identify (1) patient groups that benefit most and (2) exercise programme parameters enhancing favourable changes in primary outcome measures. Results: Ten randomized controlled studies measuring BNP or NT-pro-BNP met eligibility criteria, authors provided individual patient data for 565 patients (313 exercise and 252 controls). Exercise training had favourable effects on BNP (-28.3%, p <0.0001), NT-pro-BNP (-37.4%, p = <0.0001), and peak VO2 (17.8%, p <0.0001). The analysis showed a significant change in primary outcome measures; moreover, change in BNP (r = -0.31, p <0.0001) and NT-pro-BNP (r = -0.22, p <0.0001) were correlated with peak VO2 change. Conclusion: Exercise training has favourable effects on BNP, NT-pro-BNP, and peak VO2 in heart failure patients and BNP/NT-pro-BNP changes were correlated with peak VO2 changes.
KW - Exercise training
KW - heart failure
KW - meta-analysis
KW - natriuretic peptides
UR - http://www.scopus.com/inward/record.url?scp=84865548610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865548610&partnerID=8YFLogxK
U2 - 10.1177/1741826711409171
DO - 10.1177/1741826711409171
M3 - Article
C2 - 21543459
AN - SCOPUS:84865548610
VL - 19
SP - 428
EP - 435
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
SN - 2047-4873
IS - 3
ER -