Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopathy: The scar-to-biphasic model

Vittoria Rizzello, Arend F L Schinkel, Jeroen J. Bax, Eric Boersma, Manolis Bountioukos, Eleni C. Vourvouri, Boudewijn Krenning, Eustachio Agricola, Jos R T C Roelandt, Don Poldermans

Research output: Contribution to journalArticle

Abstract

Currently, the prediction of improvement of left ventricular (LV) ejection fraction (EF) after revascularization in patients with ischemic cardiomyopathy relies only on viable myocardium extent, whereas both the amount of viable and scar tissue may be important. A model was developed, based on the amount of viable and nonviable myocardium, to predict functional recovery. Viable and scarred myocardium was defined by dobutamine stress echocardiography (DSE) in 108 consecutive patients. LVEF before and 9 to 12 months after revascularization was assessed by radionuclide ventriculography; an improvement of ≥5% was considered significant. In the 1,089 dysfunctional segments (63%), DSE elicited biphasic response in 216 segments (20%), sustained improvement in 205 (19%), worsening in 43 (4%), and no change in 625 (57%). LVEF improved in 39 patients (36%). Only the numbers of biphasic and scar segments were predictors of improvement or no improvement of LVEF (odds ratio 1.5, 95% confidence interval 1.2 to 1.7, p

Original languageEnglish
Pages (from-to)1406-1409
Number of pages4
JournalThe American Journal of Cardiology
Volume91
Issue number12
DOIs
Publication statusPublished - Jun 15 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Rizzello, V., Schinkel, A. F. L., Bax, J. J., Boersma, E., Bountioukos, M., Vourvouri, E. C., Krenning, B., Agricola, E., Roelandt, J. R. T. C., & Poldermans, D. (2003). Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopathy: The scar-to-biphasic model. The American Journal of Cardiology, 91(12), 1406-1409. https://doi.org/10.1016/S0002-9149(03)00389-8