TY - JOUR
T1 - Individual prediction of functional recovery after coronary revascularization in patients with ischemic cardiomyopathy
T2 - The scar-to-biphasic model
AU - Rizzello, Vittoria
AU - Schinkel, Arend F L
AU - Bax, Jeroen J.
AU - Boersma, Eric
AU - Bountioukos, Manolis
AU - Vourvouri, Eleni C.
AU - Krenning, Boudewijn
AU - Agricola, Eustachio
AU - Roelandt, Jos R T C
AU - Poldermans, Don
PY - 2003/6/15
Y1 - 2003/6/15
N2 - Currently, the prediction of improvement of left ventricular (LV) ejection fraction (EF) after revascularization in patients with ischemic cardiomyopathy relies only on viable myocardium extent, whereas both the amount of viable and scar tissue may be important. A model was developed, based on the amount of viable and nonviable myocardium, to predict functional recovery. Viable and scarred myocardium was defined by dobutamine stress echocardiography (DSE) in 108 consecutive patients. LVEF before and 9 to 12 months after revascularization was assessed by radionuclide ventriculography; an improvement of ≥5% was considered significant. In the 1,089 dysfunctional segments (63%), DSE elicited biphasic response in 216 segments (20%), sustained improvement in 205 (19%), worsening in 43 (4%), and no change in 625 (57%). LVEF improved in 39 patients (36%). Only the numbers of biphasic and scar segments were predictors of improvement or no improvement of LVEF (odds ratio 1.5, 95% confidence interval 1.2 to 1.7, p
AB - Currently, the prediction of improvement of left ventricular (LV) ejection fraction (EF) after revascularization in patients with ischemic cardiomyopathy relies only on viable myocardium extent, whereas both the amount of viable and scar tissue may be important. A model was developed, based on the amount of viable and nonviable myocardium, to predict functional recovery. Viable and scarred myocardium was defined by dobutamine stress echocardiography (DSE) in 108 consecutive patients. LVEF before and 9 to 12 months after revascularization was assessed by radionuclide ventriculography; an improvement of ≥5% was considered significant. In the 1,089 dysfunctional segments (63%), DSE elicited biphasic response in 216 segments (20%), sustained improvement in 205 (19%), worsening in 43 (4%), and no change in 625 (57%). LVEF improved in 39 patients (36%). Only the numbers of biphasic and scar segments were predictors of improvement or no improvement of LVEF (odds ratio 1.5, 95% confidence interval 1.2 to 1.7, p
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U2 - 10.1016/S0002-9149(03)00389-8
DO - 10.1016/S0002-9149(03)00389-8
M3 - Article
C2 - 12804724
AN - SCOPUS:12444344280
VL - 91
SP - 1406
EP - 1409
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12
ER -