TY - JOUR
T1 - Indocyanine Green Nanoparticles
T2 - Are They Compelling for Cancer Treatment?
AU - Sevieri, Marta
AU - Silva, Filippo
AU - Bonizzi, Arianna
AU - Sitia, Leopoldo
AU - Truffi, Marta
AU - Mazzucchelli, Serena
AU - Corsi, Fabio
N1 - Funding Information:
SM acknowledges Pediatric Clinical Research Center Romeo and Enrica Invernizzi that supports her position. LS and AB postdoctoral and doctoral fellowships are supported by University of Milan. The authors acknowledge University of Milan for support in open access publication.
Publisher Copyright:
© Copyright © 2020 Sevieri, Silva, Bonizzi, Sitia, Truffi, Mazzucchelli and Corsi.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7/16
Y1 - 2020/7/16
N2 - Indocyanine green (ICG) is a Food and Drug Administration–approved near-infrared fluorescent dye, employed as an imaging agent for different clinical applications due to its attractive physicochemical properties, high sensitivity, and safety. However, free ICG suffers from some drawbacks, such as relatively short circulation half-life, concentration-dependent aggregation, and rapid clearance from the body, which would confine its feasible application in oncology. Here, we aim to discuss encapsulation of ICG within a nanoparticle formulation as a strategy to overcome some of its current limitations and to enlarge its possible applications in cancer diagnosis and treatment. Our purpose is to provide a short but exhaustive overview of clinical outcomes that these nanocomposites would provide, discussing opportunities, limitations, and possible impacts with regard to the main clinical needs in oncology.
AB - Indocyanine green (ICG) is a Food and Drug Administration–approved near-infrared fluorescent dye, employed as an imaging agent for different clinical applications due to its attractive physicochemical properties, high sensitivity, and safety. However, free ICG suffers from some drawbacks, such as relatively short circulation half-life, concentration-dependent aggregation, and rapid clearance from the body, which would confine its feasible application in oncology. Here, we aim to discuss encapsulation of ICG within a nanoparticle formulation as a strategy to overcome some of its current limitations and to enlarge its possible applications in cancer diagnosis and treatment. Our purpose is to provide a short but exhaustive overview of clinical outcomes that these nanocomposites would provide, discussing opportunities, limitations, and possible impacts with regard to the main clinical needs in oncology.
KW - cancer
KW - diagnosis
KW - indocyanine green (ICG)
KW - nanoparticles
KW - treatment
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U2 - 10.3389/fchem.2020.00535
DO - 10.3389/fchem.2020.00535
M3 - Review article
AN - SCOPUS:85088814881
VL - 8
JO - Frontiers in Chemistry
JF - Frontiers in Chemistry
SN - 2296-2646
M1 - 535
ER -