Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenesis of autoimmune diseases; we investigated whether changes in IDO gene expression and activity could be indicative of onset of relapse inmultiple sclerosis (MS) patients.

Original languageEnglish
Article numbere0130715
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 25 2015

Fingerprint

Indoleamine-Pyrrole 2,3,-Dioxygenase
Relapsing-Remitting Multiple Sclerosis
sclerosis
T-cells
Lymphocytes
autoimmune diseases
relapse
Sclerosis
Transcription
interferon-gamma
Gene expression
Tryptophan
tryptophan
Autoimmune Diseases
Interferon-gamma
lymphocytes
pathogenesis
transcription (genetics)
T-lymphocytes
Chemical activation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis. / Mancuso, Roberta; Hernis, Ambra; Agostini, Simone; Rovaris, Marco; Caputo, Domenico; Fuchs, Dietmar; Clerici, Mario.

In: PLoS One, Vol. 10, No. 6, e0130715, 25.06.2015.

Research output: Contribution to journalArticle

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