Indoleamine 2,3 dioxygenase (IDO) expression and activity in relapsing-remitting multiple sclerosis

Research output: Contribution to journalArticle

Abstract

Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenesis of autoimmune diseases; we investigated whether changes in IDO gene expression and activity could be indicative of onset of relapse inmultiple sclerosis (MS) patients.

Original languageEnglish
Article numbere0130715
JournalPLoS One
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 25 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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