Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater

M. Gabriella Buzzi, Damianos E. Sakas, Michael A. Moskowitz

Research output: Contribution to journalArticle

Abstract

Leakage of 125I-bovine serum albumin was measured in rat dura mater, conjuctiva, eyelid and lip, after unilateral electrical stimulation of the trigeminal ganglion. In one animal, 99Tc-human serum albumin leakage was imaged in ipsilateral facial tissues. Pretreatment with indomethacin 1 mg/kg i.p. decreased leakage in dura mater but not in extracranial tissues. When extravasation was expressed as a ratio of stimulated to unstimulated sides, indomethacin 1 mg/kg, or acetylsalicylic acid 50 mg/kg decreased this ratio from 1.80 to 1.27 (P

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalEuropean Journal of Pharmacology
Volume165
Issue number2-3
DOIs
Publication statusPublished - Jun 20 1989

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Keywords

  • Antiinflammatory drugs
  • Dura mater
  • Neurogenic inflammation
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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