Induced sputum in the management of COPD: Clinical implications

Andrea Zanini, S. Della Patrona, A. L. Facchini, A. Spanevello

Research output: Contribution to journalArticlepeer-review


Sputum induction can be used as a non-invasive technique to investigate airway inflammation in asthma and COPD. We reported the case of a 68 year old man with COPD, stage III GOLD, that underwent sputum induction during two exacerbation episodes. The first cell count showed a typical sputum neutrophilia, whereas the second showedsputum eosinophilia. On the basis of sputum cellularity, we decided to treat the first episode with a course of antibiotics and the second exacerbation with a course of antibiotics and oral steroids. The patient showed improvement in both cases, obtaining clinical stabilisation. The induced sputum cell count could be a useful technique in a clinical setting to evaluate the cellular characteristics of airway inflammation during COPD exacerbation and modulate the antinflammatory therapy.

Original languageEnglish
Pages (from-to)23-25
Number of pages3
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number1
Publication statusPublished - Mar 2012


  • Airway inflammation
  • COPD
  • Induced sputum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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