Induced sputum in the management of COPD: Clinical implications

Andrea Zanini; S. Della Patrona; A. L. Facchini; A. Spanevello

Induced sputum in the management of COPD: Clinical implications

Andrea Zanini, S. Della Patrona, A. L. Facchini, A. Spanevello

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Sputum induction can be used as a non-invasive technique to investigate airway inflammation in asthma and COPD. We reported the case of a 68 year old man with COPD, stage III GOLD, that underwent sputum induction during two exacerbation episodes. The first cell count showed a typical sputum neutrophilia, whereas the second showedsputum eosinophilia. On the basis of sputum cellularity, we decided to treat the first episode with a course of antibiotics and the second exacerbation with a course of antibiotics and oral steroids. The patient showed improvement in both cases, obtaining clinical stabilisation. The induced sputum cell count could be a useful technique in a clinical setting to evaluate the cellular characteristics of airway inflammation during COPD exacerbation and modulate the antinflammatory therapy.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Monaldi Archives for Chest Disease - Cardiac Series
Volume	77
Issue number	1
Publication status	Published - Mar 2012

Keywords

Airway inflammation
COPD
Induced sputum

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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AB - Sputum induction can be used as a non-invasive technique to investigate airway inflammation in asthma and COPD. We reported the case of a 68 year old man with COPD, stage III GOLD, that underwent sputum induction during two exacerbation episodes. The first cell count showed a typical sputum neutrophilia, whereas the second showedsputum eosinophilia. On the basis of sputum cellularity, we decided to treat the first episode with a course of antibiotics and the second exacerbation with a course of antibiotics and oral steroids. The patient showed improvement in both cases, obtaining clinical stabilisation. The induced sputum cell count could be a useful technique in a clinical setting to evaluate the cellular characteristics of airway inflammation during COPD exacerbation and modulate the antinflammatory therapy.

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