Abstract
Background: To evaluate feasibility and safety of induction three-drugs combination chemotherapy and concurrent radio-chemotherapy in stage IIIB NSCLC. Patients and Methods: Patients with stage IIIB NSCLC were treated with three courses of induction chemotherapy, cisplatin 50 mg/m2, paclitaxel 125 mg/m2 and gemcitabine 1000 mg/m2 on days 1,8 of every 21 day cycle. Patients without distant progressive disease were then treated with radiotherapy and concurrent weekly gemcitabine (250 mg/m2). Toxicity and response of radio-chemotherapy treatment have been assessed. Results: Between Jan 01 and Nov 02, 46 patients were enrolled. Grade 3+ hematological and non-hematological toxicity during the induction phase were 41.3% and 13.1%, respectively. In 38 patients a Clinical Response or Stable Disease was recorded and these patients underwent to concurrent radio-chemotherapy. Grade 3+ hematological and non-hematological toxicities were 8.2% in this group. Further response was observed in 66% of patients. Overall median survival time was 17.8 months, with a 3-year survival rates of 23%. Conclusion: Three-drugs induction chemotherapy and concurrent radio-chemotherapy with weekly gemcitabine in locally advanced stage IIIB NSCLC is feasible and safe.
Original language | English |
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Pages (from-to) | 331-338 |
Number of pages | 8 |
Journal | Lung Cancer |
Volume | 54 |
Issue number | 3 |
DOIs | |
Publication status | Published - Dec 2006 |
Keywords
- Chemoradiation
- Concurrent radio-chemotherapy
- Conformal radiotherapy
- Gemcitabine
- Induction chemotherapy
- Locally advanced disease
- Non-small cell lung cancer
- Phase II trial
ASJC Scopus subject areas
- Oncology