Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression

Nicoletta Ferrari, Laura Paleari, Giulio L. Palmisano, Paolo Tammaro, Giovanni Levi, Adriana Albini, Claudio Brigati

Research output: Contribution to journalArticle

Abstract

We investigated a possible relationship between apoptosis induction by fenretinide (4HPR) and the expression of a group of genes thought to be essential in morphogenesis and development, the DLX genes. We analyzed their expression under normal conditions or upon 4HPR stimulation in several tumor cell lines. We show that DLX2, DLX3 and DLX4 were expressed at higher levels in cell lines which where more sensitive to apoptotic induction, whereas DLX 5 and 6 appeared to segregate in a distinct functional compartment. Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients.

Original languageEnglish
Pages (from-to)973-977
Number of pages5
JournalOncology Reports
Volume10
Issue number4
Publication statusPublished - Jul 2003

Keywords

  • Apoptosis
  • DLX genes
  • Fenretinide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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