Induction of apoptotic cell death by IFNβ on HPV-16 transformed human keratinocytes

Federico De Marco, Vanessa Manni, Nicolino Guaricci, Antonio Muller, Maria Luisa Marcante

Research output: Contribution to journalArticlepeer-review


Apoptosis, or 'programmed cell death' is a process of general biological relevance with implications in several physiological and pathological conditions of the skin. However, little is known about its induction in keratinocytes by regulator agents. In this work we demonstrate that IFNβ, but not IFNα, selectively induces programmed cell death in HPK-Ia cells, a line derived from human keratinocytes transformed with HPV-16 DNA. This IFNβ-triggered apoptosis is strictly dependent on a serum-induced partially differentiated phenotype; it occurs through the activation of a check point in the early 'S' phase, where the cells are arrested and eventually driven to apoptosis. These data indicate that apoptosis may be induced in keratinocytes by a regulator agent combined with a differentiating stimulus. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalAntiviral Research
Issue number2
Publication statusPublished - Jun 1999


  • Apoptotic cell death
  • Human keratinocytes
  • IFNβ

ASJC Scopus subject areas

  • Virology
  • Pharmacology


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