Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation

R. Adatia, A. Albini, A. Colacci, C. De Giovanni, P. Nanni, D. Giunciuglio, S. Parodi, S. Grilli, P. Perocco

Research output: Contribution to journalArticlepeer-review

Abstract

1,2-Dibromoethane (DBE), which can act as initiating agent, is capable of inducing a malignant phenotype in BALB/c 3T3 cells. Cells transformed with a single noncytotoxic dose formed more progressive tumors in vivo. Almost all animals (95%) receiving the inoculum of two different transformed clones developed tumors within 1 month. In the control group only 55% of the animals developed tumors after 4 months. Treatment with DBE also increased the chemotactic properties of target cells, which also acquired ability to penetrate and colonize a reconstituted basal membrane (matrigel). These data suggest that DBE could play a key role in tumor progression.

Original languageEnglish
Pages (from-to)234-243
Number of pages10
JournalInvasion and Metastasis
Volume13
Issue number5
Publication statusPublished - 1993

Keywords

  • 1,2-Dibromoethane
  • Invasion
  • Tumor progression

ASJC Scopus subject areas

  • Cancer Research

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