Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation

R. Adatia; A. Albini; A. Colacci; C. De Giovanni; P. Nanni; D. Giunciuglio; S. Parodi; S. Grilli; P. Perocco

Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation

R. Adatia, A. Albini, A. Colacci, C. De Giovanni, P. Nanni, D. Giunciuglio, S. Parodi, S. Grilli, P. Perocco

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

1,2-Dibromoethane (DBE), which can act as initiating agent, is capable of inducing a malignant phenotype in BALB/c 3T3 cells. Cells transformed with a single noncytotoxic dose formed more progressive tumors in vivo. Almost all animals (95%) receiving the inoculum of two different transformed clones developed tumors within 1 month. In the control group only 55% of the animals developed tumors after 4 months. Treatment with DBE also increased the chemotactic properties of target cells, which also acquired ability to penetrate and colonize a reconstituted basal membrane (matrigel). These data suggest that DBE could play a key role in tumor progression.

Original language	English
Pages (from-to)	234-243
Number of pages	10
Journal	Invasion and Metastasis
Volume	13
Issue number	5
Publication status	Published - 1993

Keywords

1,2-Dibromoethane
Invasion
Tumor progression

ASJC Scopus subject areas

Cancer Research

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abstract = "1,2-Dibromoethane (DBE), which can act as initiating agent, is capable of inducing a malignant phenotype in BALB/c 3T3 cells. Cells transformed with a single noncytotoxic dose formed more progressive tumors in vivo. Almost all animals (95%) receiving the inoculum of two different transformed clones developed tumors within 1 month. In the control group only 55% of the animals developed tumors after 4 months. Treatment with DBE also increased the chemotactic properties of target cells, which also acquired ability to penetrate and colonize a reconstituted basal membrane (matrigel). These data suggest that DBE could play a key role in tumor progression.",

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T1 - Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation

AU - Adatia, R.

AU - Albini, A.

AU - Colacci, A.

AU - De Giovanni, C.

AU - Nanni, P.

AU - Giunciuglio, D.

AU - Parodi, S.

AU - Grilli, S.

AU - Perocco, P.

PY - 1993

Y1 - 1993

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AB - 1,2-Dibromoethane (DBE), which can act as initiating agent, is capable of inducing a malignant phenotype in BALB/c 3T3 cells. Cells transformed with a single noncytotoxic dose formed more progressive tumors in vivo. Almost all animals (95%) receiving the inoculum of two different transformed clones developed tumors within 1 month. In the control group only 55% of the animals developed tumors after 4 months. Treatment with DBE also increased the chemotactic properties of target cells, which also acquired ability to penetrate and colonize a reconstituted basal membrane (matrigel). These data suggest that DBE could play a key role in tumor progression.

KW - 1,2-Dibromoethane

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KW - Tumor progression

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Induction of chemotactic and invasive phenotype in BALB/c 3T3 cells by 1,2-dibromoethane transformation

Abstract

Keywords

ASJC Scopus subject areas

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