Induction of complete regressions of oncogene-induced breast tumors in mice

R. Benezra, E. Henke, A. Ciarrocchi, M. Ruzinova, D. Solit, N. Rosen, D. Nolan, V. Mittal, P. De Candia

Research output: Contribution to journalArticle

Abstract

Over the past decade, mouse models of cancer have come to resemble human disease much more closely than simple subcutaneous or orthotopic systems. Intervention strategies that work on these new model systems are more likely to have an impact clinically. We have shown recently that antiangiogenic stress imposed by loss of Id protein in endothelial progenitor cells results in dramatic central necrosis in breast tumors initiated in mice by overexpression of the her2/neu oncogene. Tumor cells remain viable at the periphery, perhaps via the hypoxic response pathway which allows the lesions to expand. Inhibition of this pathway by the inactivation of the Hif-1α chaperone Hsp90 in combination with antiangiogenic stress leads to the first reported complete regression of these aggressive breast tumors.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume70
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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