Abstract
Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.
| Original language | English |
|---|---|
| Pages (from-to) | 318-329 |
| Number of pages | 12 |
| Journal | Enzyme |
| Volume | 15 |
| Issue number | 1-6 |
| Publication status | Published - 1973 |
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ASJC Scopus subject areas
- Biochemistry
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Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant. / Sereni, F.; Mandelli, M.; Principi, N.; Tognoni, G.; Pardi, G.; Morselli, P. L.
In: Enzyme, Vol. 15, No. 1-6, 1973, p. 318-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant
AU - Sereni, F.
AU - Mandelli, M.
AU - Principi, N.
AU - Tognoni, G.
AU - Pardi, G.
AU - Morselli, P. L.
PY - 1973
Y1 - 1973
N2 - Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.
AB - Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015719219&partnerID=8YFLogxK
M3 - Article
C2 - 4784711
AN - SCOPUS:0015719219
VL - 15
SP - 318
EP - 329
JO - Enzyme
JF - Enzyme
SN - 0013-9432
IS - 1-6
ER -