Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

F. Sereni, M. Mandelli, N. Principi, G. Tognoni, G. Pardi, P. L. Morselli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.

Original languageEnglish
Pages (from-to)318-329
Number of pages12
JournalEnzyme
Volume15
Issue number1-6
Publication statusPublished - 1973

Fingerprint

Enzyme activity
Phenobarbital
Diazepam
Metabolites
Metabolism
Human Activities
Fetus
Parturition
Newborn Infant
Plasmas
Enzymes
Pharmaceutical Preparations
Pregnancy
barbituric acid

ASJC Scopus subject areas

  • Biochemistry

Cite this

Sereni, F., Mandelli, M., Principi, N., Tognoni, G., Pardi, G., & Morselli, P. L. (1973). Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant. Enzyme, 15(1-6), 318-329.

Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant. / Sereni, F.; Mandelli, M.; Principi, N.; Tognoni, G.; Pardi, G.; Morselli, P. L.

In: Enzyme, Vol. 15, No. 1-6, 1973, p. 318-329.

Research output: Contribution to journalArticle

Sereni, F, Mandelli, M, Principi, N, Tognoni, G, Pardi, G & Morselli, PL 1973, 'Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant', Enzyme, vol. 15, no. 1-6, pp. 318-329.
Sereni F, Mandelli M, Principi N, Tognoni G, Pardi G, Morselli PL. Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant. Enzyme. 1973;15(1-6):318-329.
Sereni, F. ; Mandelli, M. ; Principi, N. ; Tognoni, G. ; Pardi, G. ; Morselli, P. L. / Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant. In: Enzyme. 1973 ; Vol. 15, No. 1-6. pp. 318-329.
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