Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

F. Sereni; M. Mandelli; N. Principi; G. Tognoni; G. Pardi; P. L. Morselli

Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

F. Sereni, M. Mandelli, N. Principi, G. Tognoni, G. Pardi, P. L. Morselli

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.

Original language	English
Pages (from-to)	318-329
Number of pages	12
Journal	Enzyme
Volume	15
Issue number	1-6
Publication status	Published - 1973

ASJC Scopus subject areas

Biochemistry

Cite this

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title = "Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant",

abstract = "Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.",

author = "F. Sereni and M. Mandelli and N. Principi and G. Tognoni and G. Pardi and Morselli, {P. L.}",

year = "1973",

language = "English",

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pages = "318--329",

journal = "Enzyme",

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AU - Sereni, F.

AU - Mandelli, M.

AU - Principi, N.

AU - Tognoni, G.

AU - Pardi, G.

AU - Morselli, P. L.

PY - 1973

Y1 - 1973

N2 - Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.

AB - Diazepam metabolism was followed in 5 newborns exposed to phenobarbital either during fetal life or after birth. A considerable increase of urinary metabolites and of plasma apparent K(el) was observed in comparison with newborns not exposed to the barbiturate. These findings may be considered as indirect evidence of induction of drug metabolizing enzymes during the last part of gestation and shortly after birth.

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C2 - 4784711

AN - SCOPUS:0015719219

VL - 15

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SN - 0013-9332

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Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

Abstract

ASJC Scopus subject areas

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