Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8

Ji Ming Wang; Giulia Taraboletti; Kouji Matsushima; Jo Van Damme; Alberto Mantovani

doi:10.1016/0006-291X(90)91449-3

Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8

Ji Ming Wang, Giulia Taraboletti, Kouji Matsushima, Jo Van Damme, Alberto Mantovani

Research output: Contribution to journal › Article

Abstract

Natural or recombinant neutrophil activating cytokine (IL-8) induced migration across polycarbonate filters of human A 2058 melanoma cells. Anti-IL-8 antibodies blocked IL-8 induced melanoma cell migration. Checkerboard experiments revealed a gradient-dependent response of A2058 melanoma cells to IL-8. Filters exposed to IL-8 and washed supported melanoma cell migration, thus implying a haptotactic component in the response. The homologous polypeptide platelet factor 4 was inactive. The observation that IL-8 affects melanoma cells emphasizes the need for a comprehensive analysis of the spectrum of action of platelet factor 4-related peptides. The effect of the inflammatory cytokine IL-8 on melanoma cells may be relevant to augmented secondary localization of tumors at sites of inflammation.

Original language	English
Pages (from-to)	165-170
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	169
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(90)91449-3
Publication status	Published - May 31 1990

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Wang, J. M., Taraboletti, G., Matsushima, K., Van Damme, J., & Mantovani, A. (1990). Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8. Biochemical and Biophysical Research Communications, 169(1), 165-170. https://doi.org/10.1016/0006-291X(90)91449-3

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abstract = "Natural or recombinant neutrophil activating cytokine (IL-8) induced migration across polycarbonate filters of human A 2058 melanoma cells. Anti-IL-8 antibodies blocked IL-8 induced melanoma cell migration. Checkerboard experiments revealed a gradient-dependent response of A2058 melanoma cells to IL-8. Filters exposed to IL-8 and washed supported melanoma cell migration, thus implying a haptotactic component in the response. The homologous polypeptide platelet factor 4 was inactive. The observation that IL-8 affects melanoma cells emphasizes the need for a comprehensive analysis of the spectrum of action of platelet factor 4-related peptides. The effect of the inflammatory cytokine IL-8 on melanoma cells may be relevant to augmented secondary localization of tumors at sites of inflammation.",

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