Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor

Giorgio Aicardi, Emanuela Argilli, Silvia Cappello, Spartaco Santi, Massimo Riccio, Hans Thoenen, Marco Canossa

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Neurotrophins play an important role in modulating activity-dependent neuronal plasticity. In particular, threshold levels of brain-derived neurotrophic factor (BDNF) are required to induce long-term potentiation (LTP) in acute hippocampal slices. Conversely, the administration of exogenous BDNF prevents the induction of long-term depression (LTD) in the visual cortex. A long-standing missing link in the analysis of this modulatory role of BDNF was the determination of the time-course of endogenous BDNF secretion in the same organotypic preparation in which LTP and LTD are elicited. Here, we fulfilled this requirement in slices of perirhinal cortex. Classical theta-burst stimulation patterns evoking LTP lasting >180 min elicited a large increase in BDNF secretion that persisted 5-12 min beyond the stimulation period. Weaker theta-burst stimulation patterns leading only to the initial phase of LTP (≈35 min) were accompanied by a smaller increase in BDNF secretion lasting

Original languageEnglish
Pages (from-to)15788-15792
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number44
DOIs
Publication statusPublished - Nov 2 2004

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Long-Term Potentiation
Brain-Derived Neurotrophic Factor
Neuronal Plasticity
Nerve Growth Factors
Visual Cortex

ASJC Scopus subject areas

  • Genetics
  • General

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Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor. / Aicardi, Giorgio; Argilli, Emanuela; Cappello, Silvia; Santi, Spartaco; Riccio, Massimo; Thoenen, Hans; Canossa, Marco.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 44, 02.11.2004, p. 15788-15792.

Research output: Contribution to journalArticle

Aicardi, Giorgio ; Argilli, Emanuela ; Cappello, Silvia ; Santi, Spartaco ; Riccio, Massimo ; Thoenen, Hans ; Canossa, Marco. / Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 44. pp. 15788-15792.
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